Cemin Roberto, Daves Massimo
1 Department of Cardiology, San Maurizio Regional Hospital of Bolzano, Bolzano, Italy ; 2 Clinical Pathology Laboratory, Hospital of Merano, Merano, Italy.
J Thorac Dis. 2015 Oct;7(10):E395-401. doi: 10.3978/j.issn.2072-1439.2015.10.03.
The impact of laboratory medicine on clinical cardiology has dramatically increased over the years and a lot of cardiovascular biomarkers have been recently proposed. In order to avoid clinical mistakes, physicians should be well aware of all the aspects, which could affect the quality of laboratory results, remembering that pre-analytic variability is an often overlooked significant source of bias, determining the vast majority of laboratory errors. This review addresses the determinants of pre-analitycal variability in cardiovascular biomarker testing, focusing on the most widespread biomarkers, which are cardiac troponins and natriuretic peptides.
近年来，检验医学对临床心脏病学的影响显著增加，最近提出了许多心血管生物标志物。为避免临床误诊，医生应充分了解可能影响检验结果质量的所有方面，要记住分析前的变异性是一个常被忽视的重大偏差来源，它导致了绝大多数的检验误差。本综述探讨了心血管生物标志物检测中分析前变异性的决定因素，重点关注最常用的生物标志物，即心肌肌钙蛋白和利钠肽。
