Yang Zhen, Liu Jiaqi, Zhu Ningwen, Qi Fazhi
Department of Plastic Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Department of Dermatology, Huashan Hospital, Fudan University Shanghai 200433, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):15822-7. eCollection 2015.
Several clinical research studies have demonstrated that chronic cutaneous wounds can be treated with hair follicle grafts. However, the clinical outcomes of hair follicle grafting compared to split-thickness skin grafting have not been examined. This study sought to compare the clinical outcomes of patients with chronic wounds following hair follicle therapy and split-thickness skin graft therapy in a relatively large cohort of patients. Forty patients were enrolled in the study, a retrospective analysis of all patients underwent therapy with hair follicles (cohort A) and split-thickness skin grafts (cohort B) was performed. Safety, healing duration, skin quality (recipient site), scar formation (donor site) and overall postoperative outcome were analyzed. The wound sites were examined using photography at weeks 2, 8, and 12 after surgery. Five non-biased reviewers estimated the above-mentioned clinical outcomes using a five-point Likert scale. The ages and wound areas were similar between cohorts A (n=20) and B (n=20). Total wound closure was observed and adverse events were rare and controllable in both cohorts. The skin and scar quality were rated significantly higher in the hair follicle cohort than the split-thickness skin graft cohort (4.40 vs 3.45, P<0.05 and 4.65 vs 3.20, P<0.05; respectively). Hair follicle therapy resulted in a significantly higher overall score than split-thickness skin graft treatment (4.45 vs 3.40, P<0.05). This study demonstrated that hair follicles can achieve better skin/scar quality and overall clinical outcomes than split-thickness skin grafts. Hair follicles should be considered an effective surgical technique for the treatment of chronic cutaneous wounds.
多项临床研究表明，慢性皮肤伤口可用毛囊移植治疗。然而，与断层皮片移植相比，毛囊移植的临床效果尚未得到检验。本研究旨在比较在相对大量的患者队列中，毛囊治疗和断层皮片移植治疗慢性伤口患者的临床效果。40名患者纳入本研究，对所有接受毛囊治疗的患者（A组）和断层皮片移植治疗的患者（B组）进行回顾性分析。分析安全性、愈合时间、皮肤质量（受区）、瘢痕形成（供区）及总体术后效果。术后第2周、第8周和第12周对伤口部位进行拍照检查。5名无偏见的评估者使用五点李克特量表评估上述临床效果。A组（n = 20）和B组（n = 20）的年龄和伤口面积相似。两组均观察到伤口完全闭合，不良事件罕见且可控。毛囊移植组的皮肤和瘢痕质量评分显著高于断层皮片移植组（分别为4.40对3.45，P<0.05；4.65对3.20，P<0.05）。毛囊治疗的总体评分显著高于断层皮片移植治疗（4.45对3.40，P<0.05）。本研究表明，与断层皮片移植相比，毛囊移植可获得更好的皮肤/瘢痕质量和总体临床效果。毛囊移植应被视为治疗慢性皮肤伤口的一种有效手术技术。
