钯催化的烯烃分子内氨三氟甲氧基化反应。
Palladium-Catalyzed Intramolecular Aminotrifluoromethoxylation of Alkenes.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2015 Dec 23;137(50):15648-51. doi: 10.1021/jacs.5b10971. Epub 2015 Dec 10.
The first catalytic trifluoromethoxylation of unactivated alkenes has been developed, in which Pd(CH3CN)2Cl2 was used as catalyst, AgOCF3 as trifluoromethoxide source, and Selectfluor-BF4 as oxidant. A variety of 3-OCF3 substituted piperidines were selectively obtained in good yields. Direct evidence was provided to address the facile reductive elimination of Pd(IV)-OCF3 complex to form sp(3) C-OCF3 bond.
已开发出首例未活化烯烃的催化三氟甲氧基化反应，该反应以 Pd(CH3CN)2Cl2 为催化剂、AgOCF3 为三氟甲氧基源、Selectfluor-BF4 为氧化剂。以良好的收率选择性地获得了多种 3-OCF3 取代的哌啶。提供了直接证据来阐明 Pd(IV)-OCF3 配合物的易还原消除形成 sp(3) C-OCF3 键。
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