一项在全科医疗中进行的灭活单价甲型流感疫苗对照试验。
A controlled trial of inactivated monovalent influenza A vaccines in general practice.
作者信息
Mair H J, Sansome D A, Tillett H E
出版信息
J Hyg (Lond). 1974 Oct;73(2):317-27. doi: 10.1017/s0022172400024189.
Abstract
A trial of influenza A vaccines in general practice is described. Five hundred and seven subjects were vaccinated with either inactivated monovalent A/Hong Kong vaccine, A/England vaccine or influenza B vaccine as control. Local reactions were noted in 24% and general reactions in 12% of patients. Antibody titres in serum were measured by haemagglutination inhibition (HI) and complement fixation (CF) tests in 465 subjects. The influenza vaccines produced substantial increases in both homologous and heterologous antibodies as measured by the HI test and a comparatively poor response as measured by the CF test. Although clinical influenza was confirmed in only a few cases, there was serological evidence of significant subclinical infection in the control group.
摘要
本文描述了一项在普通医疗实践中进行的甲型流感疫苗试验。507名受试者分别接种了灭活单价A/香港疫苗、A/英格兰疫苗或作为对照的乙型流感疫苗。24%的患者出现局部反应，12%的患者出现全身反应。对465名受试者的血清抗体滴度进行了血凝抑制（HI）试验和补体结合（CF）试验。通过HI试验测量，流感疫苗使同源和异源抗体均大幅增加，而通过CF试验测量，反应相对较差。尽管仅在少数病例中确诊为临床流感，但对照组有血清学证据表明存在明显的亚临床感染。
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