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从文蛤（Meretrix meretrix Linnaeus）中分离得到的一种多糖的结构与免疫活性表征

Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus.

作者信息

Li Li, Li Heng, Qian Jianying, He Yongfeng, Zheng Jialin, Lu Zhenming, Xu Zhenghong, Shi Jinsong

机构信息

School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, China.

出版信息

Mar Drugs. 2015 Dec 29;14(1):6. doi: 10.3390/md14010006.

DOI:10.3390/md14010006
PMID:26729136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4728503/
Abstract

Polysaccharides from marine clams perform various biological activities, whereas information on structure is scarce. Here, a water-soluble polysaccharide MMPX-B2 was isolated from Meretrix meretrix Linnaeus. The proposed structure was deduced through characterization and its immunological activity was investigated. MMPX-B2 consisted of d-glucose and d-galctose residues at a molar ratio of 3.51:1.00. The average molecular weight of MMPX-B2 was 510 kDa. This polysaccharide possessed a main chain of (1→4)-linked-α-d-glucopyranosyl residues, partially substituted at the C-6 position by a few terminal β-d-galactose residues or branched chains consisting of (1→3)-linked β-d-galactose residues. Preliminary immunological tests in vitro showed that MMPX-B2 could stimulate the murine macrophages to release various cytokines, and the structure-activity relationship was then established. The present study demonstrated the potential immunological activity of MMPX-B2, and provided references for studying the active ingredients in M. meretrix.

摘要

海洋蛤蜊中的多糖具有多种生物活性，然而关于其结构的信息却很匮乏。在此，从文蛤中分离出一种水溶性多糖MMPX - B2。通过表征推导其结构，并研究其免疫活性。MMPX - B2由摩尔比为3.51:1.00的d - 葡萄糖和d - 半乳糖残基组成。MMPX - B2的平均分子量为510 kDa。这种多糖具有由(1→4)连接的α - d - 吡喃葡萄糖基残基组成的主链，在C - 6位部分被一些末端β - d - 半乳糖残基或由(1→3)连接的β - d - 半乳糖残基组成的支链取代。体外初步免疫试验表明，MMPX - B2能刺激小鼠巨噬细胞释放多种细胞因子，进而建立了构效关系。本研究证明了MMPX - B2潜在的免疫活性，并为研究文蛤中的活性成分提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/0b14c24f99a4/marinedrugs-14-00006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/2f994ded395d/marinedrugs-14-00006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/af98a88e9583/marinedrugs-14-00006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/0f31948d4bb1/marinedrugs-14-00006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/b9937dfde6f3/marinedrugs-14-00006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/912f06186cc5/marinedrugs-14-00006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/0b14c24f99a4/marinedrugs-14-00006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/2f994ded395d/marinedrugs-14-00006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/af98a88e9583/marinedrugs-14-00006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/0f31948d4bb1/marinedrugs-14-00006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/b9937dfde6f3/marinedrugs-14-00006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/912f06186cc5/marinedrugs-14-00006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ada6/4728503/0b14c24f99a4/marinedrugs-14-00006-g006.jpg

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