Weiland James D
Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug;2015:1650-3. doi: 10.1109/EMBC.2015.7318692.
Electrical impedance of the retina is a critical factor in retinal prostheses, determining the intraretinal current flow and potential distribution of electrical stimulation. Previous resistivity measurements in retina were limited to healthy retina, and didn't include mouse models, a common and important animal model in retinal research. This experimental study measured the resistivity profiles of wild-type, rd1, and rd10 mice, providing basis for computational simulations and predictive modeling studies. The peak resistance frequency method has been utilized to measure the resistivity profiles of the retina cross section, and the results show agreement with previous studies in retina of normal rats and embryonic chicks. Retinal degeneration affects the width of the profile, which is in agreement with histological measurements. Degeneration also results in lower peak resistivity. The results indicate that, on the mesoscopic scale, resistivity is dominated by spatial factors, while influence of remodeling on the cellular level is not apparent under such scale.
视网膜的电阻抗是视网膜假体中的一个关键因素，它决定了视网膜内的电流流动以及电刺激的电位分布。先前对视网膜电阻率的测量仅限于健康视网膜，且未涵盖小鼠模型，而小鼠模型是视网膜研究中一种常见且重要的动物模型。本实验研究测量了野生型、rd1和rd10小鼠的电阻率分布，为计算模拟和预测建模研究提供了依据。采用峰值电阻频率法测量视网膜横截面的电阻率分布，结果与先前对正常大鼠和胚胎小鸡视网膜的研究一致。视网膜变性会影响分布的宽度，这与组织学测量结果相符。变性还会导致峰值电阻率降低。结果表明，在介观尺度上，电阻率受空间因素主导，而在此尺度下细胞水平上重塑的影响并不明显。
