汉族人群幽门螺杆菌感染与牙周病风险的关联：一项病例对照研究
Association Between Helicobacter pylori Infection and Risk of Periodontal Diseases in Han Chinese: A Case-Control Study.
作者信息
Yang Jing, Zhang Qiang, Chen Ming, Wu Wu-zhou, Wang Rong, Liu Chang-jun, Li Bei, Shi Xin-li, Du Han-song, Tan Hua-bing
机构信息
Department of Infectious Disease, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
The Key Laboratory of Cell Engineering in Guizhou Province, Affiliated Hospital of Zunyi Medical College, Zunyi Medical College, Zunyi, Guizhou, China (mainland).
出版信息
Med Sci Monit. 2016 Jan 12;22:121-6. doi: 10.12659/msm.894583.
BACKGROUND
This study was performed to test the association between Helicobacter pylori (HP) and periodontal disease (PD).
MATERIAL/METHODS: This was a case-control study in a comprehensive hospital, including all patients with newly diagnosed PD between 2012 and 2014 as cases and all patients without PD as controls, thorough periodontal examinations. Those who tested positive for HP were examined by means of polymerase chain reaction. Single and multivariate logistic regression was used to analyze the data using SPSS 19.0 software.
RESULTS
This case-control study included 212 Han Chinese non-smoking adults. The results indicated that HP-positive status significantly increased the risk of PD (2.63 times higher (odds ratio [OR]=2.63; 95% confidence interval [CI]=1.48-4.67). After adjustment for age, sex, level of education, physical exercise, body mass index, and history of alcohol and diabetes mellitus, this association remained significantly (OR=2.82, 95% CI=1.55-5.13).
CONCLUSIONS
PD might be associated with HP infection in adults and HP infection may be a significant and independent risk factor for PD.
背景
本研究旨在检测幽门螺杆菌（HP）与牙周病（PD）之间的关联。
材料/方法：这是一项在综合医院进行的病例对照研究，纳入2012年至2014年间所有新诊断为PD的患者作为病例组，所有无PD的患者作为对照组，进行全面的牙周检查。对HP检测呈阳性者采用聚合酶链反应进行检测。使用SPSS 19.0软件通过单因素和多因素逻辑回归分析数据。
结果
本病例对照研究纳入了212名汉族非吸烟成年人。结果表明，HP阳性状态显著增加了患PD的风险（高2.63倍（比值比[OR]=2.63；95%置信区间[CI]=1.48 - 4.67）。在对年龄、性别、教育程度、体育锻炼、体重指数以及酒精和糖尿病史进行调整后，这种关联仍然显著（OR=2.82，95% CI=1.55 - 5.13）。
结论
成年人的PD可能与HP感染有关，HP感染可能是PD的一个重要且独立的危险因素。
Zotero 插件