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自体血小板裂解液局部注射治疗难治性外侧上髁炎。

Autologous platelet lysate local injections for the treatment of refractory lateral epicondylitis.

作者信息

Tan Xun-xiang, Ju Hai-yang, Yan Wei, Jiang Hong-jiang, Su Jin-ping, Dong Hua-jun, Wang Ling-shuang, Zou De-bao

机构信息

Department of Bone and Joint Surgery, Wendeng Orthopaedic Hospital of Shandong Province, Wendeng, Shandong, 264400, China.

Zhejiang Xingyue Biotechnology Co., Ltd, Hangzhou, 311121, China.

出版信息

J Orthop Surg Res. 2016 Jan 25;11:17. doi: 10.1186/s13018-016-0349-2.

DOI:10.1186/s13018-016-0349-2
PMID:26809347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4727323/
Abstract

BACKGROUND

The purpose of this study was to investigate the efficacy and safety of autologous platelet lysate (APL) local injections in reducing pain and improving function in patients with refractory lateral epicondylitis.

METHODS

A total of 56 patients with refractory lateral epicondylitis were enrolled in this study. All the patients received three injections in one course of treatment. Subjective assessments include visual analog scale (VAS) pain score and Mayo elbow score before injection (baseline) and at 1, 6, and 12 months after injection.

RESULTS

Significant differences were observed in VAS and Mayo scores at baseline and at 1, 6, and 12 months after injection. Overall, the injections of APL improved local symptoms and all the patients recovered to normal elbow function with 12 months follow-up.

CONCLUSIONS

Local injections of APL resulted in favorable clinical outcomes for the treatment of lateral epicondylitis. APL could be clinically effective in the treatment of lateral epicondylitis.

摘要

背景

本研究旨在探讨自体血小板裂解液（APL）局部注射在减轻顽固性肱骨外上髁炎患者疼痛及改善功能方面的疗效和安全性。

方法

本研究共纳入56例顽固性肱骨外上髁炎患者。所有患者在一个疗程中接受三次注射。主观评估包括注射前（基线）以及注射后1个月、6个月和12个月时的视觉模拟评分（VAS）疼痛评分和梅奥肘关节评分。

结果

在基线以及注射后1个月、6个月和12个月时，VAS和梅奥评分存在显著差异。总体而言，注射APL改善了局部症状，所有患者在12个月的随访后恢复到正常肘关节功能。

结论

APL局部注射治疗肱骨外上髁炎取得了良好的临床效果。APL在治疗肱骨外上髁炎方面可能具有临床疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/a8dfb32848fa/13018_2016_349_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/c673602946d7/13018_2016_349_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/10326322ccb8/13018_2016_349_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/a8dfb32848fa/13018_2016_349_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/c673602946d7/13018_2016_349_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/10326322ccb8/13018_2016_349_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/4727323/a8dfb32848fa/13018_2016_349_Fig3_HTML.jpg

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