Vlasova Anastasia N, Kandasamy Sukumar, Chattha Kuldeep S, Rajashekara Gireesh, Saif Linda J
Food Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA.
Food Animal Health Research Program, The Ohio Agricultural Research and Development Center, Veterinary Preventive Medicine Department, The Ohio State University, Wooster, OH, USA.
Vet Immunol Immunopathol. 2016 Apr;172:72-84. doi: 10.1016/j.vetimm.2016.01.003. Epub 2016 Jan 14.
Different probiotic strains of Lactobacillus and Bifidobacterium genera possess significant and widely acknowledged health-promoting and immunomodulatory properties. They also provide an affordable means for prevention and treatment of various infectious, allergic and inflammatory conditions as demonstrated in numerous human and animal studies. Despite the ample evidence of protective effects of these probiotics against rotavirus (RV) infection and disease, the precise immune mechanisms of this protection remain largely undefined, because of limited mechanistic research possible in humans and investigated in the majority of animal models. Additionally, while most human clinical probiotic trials are well-standardized using the same strains, uniform dosages, regimens of the probiotic treatments and similar host age, animal studies often lack standardization, have variable experimental designs, and non-uniform and sometime limited selection of experimental variables or observational parameters. This review presents selected data on different probiotic strains of lactobacilli and bifidobacteria and summarizes the knowledge of their immunomodulatory properties and the associated protection against RV disease in diverse host species including neonates.
不同属的乳酸杆菌和双歧杆菌益生菌菌株具有显著且广泛认可的促进健康和免疫调节特性。正如众多人体和动物研究所示，它们还为预防和治疗各种感染性、过敏性和炎症性疾病提供了一种经济实惠的手段。尽管有充分证据表明这些益生菌对轮状病毒（RV）感染和疾病具有保护作用，但其保护的确切免疫机制在很大程度上仍不明确，这是因为在人体中进行机制研究的可能性有限，且大多数动物模型中的研究也较少。此外，虽然大多数人体临床益生菌试验使用相同菌株、统一剂量、益生菌治疗方案以及相似的宿主年龄进行了很好的标准化，但动物研究往往缺乏标准化，实验设计各异，实验变量或观察参数的选择不统一且有时有限。本综述展示了关于不同乳酸杆菌和双歧杆菌益生菌菌株的选定数据，并总结了它们在包括新生儿在内的不同宿主物种中的免疫调节特性以及对RV疾病的相关保护作用的知识。
