CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China;
Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China and.
Regen Biomater. 2015 Dec;2(4):273-80. doi: 10.1093/rb/rbv024. Epub 2015 Dec 3.
Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high efficiency. An understanding of how the physicochemical properties of Au nanomaterials affect their cell internalization is of significant interest. Studies devoted to clarify the functions of various properties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalization are under way. These fundamental investigations will give us a foundation for constructing Au nanomaterial-based biomedical devices in the future. In this review, we present the current advances and rationales in study of the relationship between the physicochemical properties of Au nanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial-cell interaction research.
金纳米材料独特的物理化学性质使它们成为生物医学应用中极具潜力的明星材料。然而，我们对于金纳米材料的基本问题仍然知之甚少，这些基本问题涉及到如何高效地将金纳米材料制备成能够进入生物系统，尤其是细胞的材料。了解金纳米材料的物理化学性质如何影响其细胞内化是非常重要的。目前正在进行研究，以阐明金纳米结构的各种性质，如尺寸、形状和表面特性，在细胞内化中的作用。这些基础研究将为我们未来构建基于金纳米材料的生物医学设备提供基础。在这篇综述中，我们介绍了金纳米材料物理化学性质与细胞摄取之间关系的研究进展和原理。我们还对金纳米材料-细胞相互作用的研究提供了一个视角。
