Deng Yaoyao, Li Erdong, Cheng Xiaju, Zhu Jing, Lu Shuanglong, Ge Cuicui, Gu Hongwei, Pan Yue
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, China.
School for Radiological and Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Nanoscale. 2016 Feb 21;8(7):3895-9. doi: 10.1039/c5nr09102k.
The hybrid platinum@iron oxide core-shell nanorods with high biocompatibility were synthesized and applied for combined therapy. These hybrid nanorods exhibit a good photothermal effect on cancer cells upon irradiation with a NIR laser. Furthermore, due to the presence of a high atomic number element (platinum core), the hybrid nanorods show a synergistic effect between photothermal and radiation therapy. Therefore, the as-prepared core-shell nanorods could play an important role in facilitating synergistic therapy between photothermal and radiation therapy to achieve better therapeutic efficacy.
合成了具有高生物相容性的混合铂@氧化铁核壳纳米棒，并将其应用于联合治疗。在用近红外激光照射时，这些混合纳米棒对癌细胞表现出良好的光热效应。此外，由于存在高原子序数元素（铂核），混合纳米棒在光热疗法和放射疗法之间表现出协同效应。因此，所制备的核壳纳米棒在促进光热疗法和放射疗法之间的协同治疗以实现更好的治疗效果方面可以发挥重要作用。
