Kiew Siaw Fui, Kiew Lik Voon, Lee Hong Boon, Imae Toyoko, Chung Lip Yong
Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
J Control Release. 2016 Mar 28;226:217-28. doi: 10.1016/j.jconrel.2016.02.015. Epub 2016 Feb 9.
Graphene oxide (GO)-based nanocarriers have been frequently studied due to their high drug loading capacity. However, the unsatisfactory biocompatibility of these GO-based nanocarriers hampers their use in clinical settings. This review discusses how each of the physicochemical characteristics (e.g., size, surface area, surface properties, number of layers and particulate states) and surface coatings on GO affect its in vitro and in vivo nanotoxicity. We provide an overview on the effect of GO properties on interactions with cells such as red blood cells, macrophages and cell lines, and experimental organisms including rodents, rabbits and Zebrafish, offering some guidelines for development of safe GO-based nanocarriers. We conclude the paper by outlining the challenges involving GO-based formulations and future perspectives of this research in the biomedical field.
基于氧化石墨烯（GO）的纳米载体因其高载药能力而受到广泛研究。然而，这些基于GO的纳米载体的生物相容性不尽人意，阻碍了它们在临床环境中的应用。本综述讨论了GO的每种物理化学特性（例如尺寸、表面积、表面性质、层数和颗粒状态）以及表面涂层如何影响其体外和体内纳米毒性。我们概述了GO特性对与红细胞、巨噬细胞和细胞系等细胞以及啮齿动物、兔子和斑马鱼等实验生物体相互作用的影响，为开发安全的基于GO的纳米载体提供了一些指导方针。我们通过概述基于GO的制剂所涉及的挑战以及该研究在生物医学领域的未来前景来结束本文。
