Smarr Melissa M, Grantz Katherine L, Zhang Cuilin, Sundaram Rajeshwari, Maisog José M, Barr Dana Boyd, Louis Germaine M Buck
Office of the Director, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA..
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA..
Sci Total Environ. 2016 May 1;551-552:285-91. doi: 10.1016/j.scitotenv.2016.02.030. Epub 2016 Feb 12.
We sought to investigate the relationship between maternal preconception exposures to persistent organic pollutants (POPs) and pregnancy complications, gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching ≥24weeks gestation, from a prospective cohort of 501 couples who discontinued contraception to attempt pregnancy, were analyzed. Preconception concentrations of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers (PBDEs) were quantified in serum. In separate multiple logistic regression models of self-reported physician diagnosed outcomes: GDM (11%) and gestational hypertension (10%), chemicals were natural log-transformed and rescaled by their standard deviation (SD). Models were adjusted for serum lipids, and then adjusted for age, body mass index, race, and smoking. Models were additionally adjusted for the sum of the remaining POPs in each chemical class. Women's serum concentration of PBDE congener 153 (PBDE-153) was positively associated with an increased odds of GDM per SD increase in log-transformed concentration, for unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 1.03-1.86) and with the sum of remaining PBDEs (OR=1.79, 95% CI: 1.18, 2.74) models. Our findings suggest that at environmentally relevant concentrations, maternal exposure to POPs prior to conception may contribute to increased chance of developing GDM.
我们试图研究孕前母亲接触持久性有机污染物（POPs）与妊娠并发症、妊娠期糖尿病（GDM）和妊娠期高血压之间的关系。对来自501对停止避孕尝试怀孕的夫妇的前瞻性队列中258名（51%）人绒毛膜促性腺激素（hCG）确诊妊娠达到≥24周的妇女的数据进行了分析。对血清中9种有机氯农药（OCPs）和10种多溴二苯醚（PBDEs）的孕前浓度进行了定量。在自我报告的医生诊断结果（GDM，11%；妊娠期高血压，10%）的单独多因素逻辑回归模型中，对化学物质进行自然对数转换并按其标准差（SD）重新标度。模型先根据血清脂质进行调整，然后根据年龄、体重指数、种族和吸烟情况进行调整。模型还根据每个化学类别中其余POPs的总和进行了调整。对于未调整（OR = 1.36，95%CI：1.02 - 1.81）、先验调整（OR = 1.38，95%CI：1.03 - 1.86）以及与其余PBDEs总和相关的模型（OR = 1.79，95%CI：1.18，2.74），女性血清中多溴二苯醚同系物153（PBDE - 153）的浓度与对数转换浓度每增加一个标准差时GDM发生几率的增加呈正相关。我们的研究结果表明，在环境相关浓度下，孕前母亲接触POPs可能会增加患GDM的几率。
