Cichońska Dominika, Król Oliwia, Słomińska Ewa M, Kochańska Barbara, Świetlik Dariusz, Ochocińska Jolanta, Kusiak Aida
Department of Periodontology and Oral Mucosa Diseases, Medical University of Gdansk, 80-210 Gdansk, Poland.
Department of Biochemistry, Medical University of Gdansk, 80-210 Gdansk, Poland.
Toxics. 2021 Oct 14;9(10):263. doi: 10.3390/toxics9100263.
The balance between reactive oxygen species production and the activity of antioxidant systems present in saliva is an important element in maintaining oral environment homeostasis. E-cigarettes adversely affect the oral cavity and their cytotoxic effect is related to oxidative stress. The aim of this study was to assess the influence of using electronic cigarettes on antioxidant capacity of saliva. The study involved 110 subjects (35 e-cigarettes users, 33 traditional cigarettes smokers and 42 non-smokers). Laboratory analysis involved quantitation of uric acid, hypoxanthine, xanthine, TAOS (total antioxidant status) and TEAC (Trolox equivalent antioxidant capacity) in saliva. Lower values for TAOS and TEAC were observed among e-cigarettes users and traditional cigarettes smokers in comparison to non-smokers. Uric acid concentration tended to be higher among e-cigarettes users while no differences in hypoxanthine and xanthine saliva concentrations were observed. Electronic cigarettes usage affects antioxidant capacity of saliva to the same extent as traditional cigarettes, when comparing smokers to non-smokers. Further longitudinal studies on a larger study group are needed to assess the effect of changes in antioxidant status on oral health.
唾液中活性氧生成与抗氧化系统活性之间的平衡是维持口腔环境稳态的重要因素。电子烟会对口腔产生不利影响，其细胞毒性作用与氧化应激有关。本研究的目的是评估使用电子烟对唾液抗氧化能力的影响。该研究涉及110名受试者（35名电子烟使用者、33名传统香烟吸烟者和42名非吸烟者）。实验室分析包括对唾液中尿酸、次黄嘌呤、黄嘌呤、总抗氧化状态（TAOS）和特洛克斯等效抗氧化能力（TEAC）进行定量。与非吸烟者相比，电子烟使用者和传统香烟吸烟者的TAOS和TEAC值较低。电子烟使用者的尿酸浓度往往较高，而次黄嘌呤和黄嘌呤的唾液浓度未观察到差异。将吸烟者与非吸烟者相比，使用电子烟对唾液抗氧化能力的影响与传统香烟相同。需要对更大的研究群体进行进一步的纵向研究，以评估抗氧化状态变化对口腔健康的影响。
