Yang Ke, Peretz-Soroka Hagit, Liu Yong, Lin Francis
Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, P. O. Box 1126, Hefei, 230031, PR China.
Lab Chip. 2016 Mar 21;16(6):943-58. doi: 10.1039/c5lc01524c. Epub 2016 Feb 22.
Portable electronic devices and wireless communication systems enable a broad range of applications such as environmental and food safety monitoring, personalized medicine and healthcare management. Particularly, hybrid smartphone and microfluidic devices provide an integrated solution for the new generation of mobile sensing applications. Such mobile sensing based on microfluidic devices (broadly defined) and smartphones (MS(2)) offers a mobile laboratory for performing a wide range of bio-chemical detection and analysis functions such as water and food quality analysis, routine health tests and disease diagnosis. MS(2) offers significant advantages over traditional platforms in terms of test speed and control, low cost, mobility, ease-of-operation and data management. These improvements put MS(2) in a promising position in the fields of interdisciplinary basic and applied research. In particular, MS(2) enables applications to remote in-field testing, homecare, and healthcare in low-resource areas. The marriage of smartphones and microfluidic devices offers a powerful on-chip operating platform to enable various bio-chemical tests, remote sensing, data analysis and management in a mobile fashion. The implications of such integration are beyond telecommunication and microfluidic-related research and technology development. In this review, we will first provide the general background of microfluidic-based sensing, smartphone-based sensing, and their integration. Then, we will focus on several key application areas of MS(2) by systematically reviewing the important literature in each area. We will conclude by discussing our perspectives on the opportunities, issues and future directions of this emerging novel field.
便携式电子设备和无线通信系统支持广泛的应用，如环境与食品安全监测、个性化医疗和医疗保健管理。特别是，智能手机与微流控设备的结合为新一代移动传感应用提供了集成解决方案。这种基于微流控设备（广义定义）和智能手机的移动传感（MS(2)）提供了一个移动实验室，可执行多种生物化学检测和分析功能，如水和食品质量分析、常规健康测试和疾病诊断。MS(2)在测试速度与控制、低成本、移动性、操作简便性和数据管理方面比传统平台具有显著优势。这些改进使MS(2)在跨学科基础研究和应用研究领域处于有利地位。特别是，MS(2)使应用能够用于远程现场测试、家庭护理以及资源匮乏地区的医疗保健。智能手机与微流控设备的结合提供了一个强大的片上操作平台，能够以移动方式进行各种生物化学测试、遥感、数据分析和管理。这种集成的影响超出了电信和微流控相关的研究与技术开发范围。在本综述中，我们将首先介绍基于微流控传感、基于智能手机传感及其集成的一般背景。然后，我们将通过系统回顾每个领域的重要文献，重点关注MS(2)的几个关键应用领域。我们将通过讨论我们对这个新兴新领域的机遇、问题和未来方向的看法来得出结论。
