通过铜（I）催化的环加成反应合成三唑连接的吗啉代寡核苷酸。
Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition.
作者信息
Palframan Matthew J, Alharthy Rima D, Powalowska Paulina K, Hayes Christopher J
机构信息
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
出版信息
Org Biomol Chem. 2016 Mar 21;14(11):3112-9. doi: 10.1039/c6ob00007j. Epub 2016 Feb 24.
Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.
使用铜（I）催化的（3 + 2）叠氮化物-炔烃环加成（CuAAC）反应合成了三唑连接的吗啉代（（TL）MO）寡核酸。通过固相合成将修饰的DNA类似物掺入13聚体序列中。紫外熔解实验表明，（TL）MO修饰比相应的（TL）DNA修饰具有更高的解链温度（Tm）值。
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