日本某医院人群中寻常型银屑病与冠心病的关联。
Association between Psoriasis Vulgaris and Coronary Heart Disease in a Hospital-Based Population in Japan.
作者信息
Shiba Masayuki, Kato Takao, Funasako Moritoshi, Nakane Eisaku, Miyamoto Shoichi, Izumi Toshiaki, Haruna Tetsuya, Inoko Moriaki
机构信息
Department of Cardiovascular Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan.
Cardiovascular Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan.
出版信息
PLoS One. 2016 Feb 24;11(2):e0149316. doi: 10.1371/journal.pone.0149316. eCollection 2016.
BACKGROUND
Psoriasis vulgaris is a chronic inflammatory skin disease with an immune-genetic background. It has been reported as an independent risk factor for coronary heart disease (CHD) in the United States and Europe. The purpose of this study was to investigate the association between psoriasis and CHD in a hospital-based population in Japan.
METHODS
For 113,065 in-hospital and clinic patients at our institution between January 1, 2011 and January 1, 2013, the diagnostic International Classification of Diseases (ICD)-10 codes for CHD, hypertension, dyslipidemia, diabetes, and psoriasis vulgaris were extracted using the medical accounting system and electronic medical record, and were analyzed.
RESULTS
The prevalence of CHD (n = 5,167, 4.5%), hypertension (n = 16,476, 14.5%), dyslipidemia (n = 9,236, 8.1%), diabetes mellitus (n = 11,555, 10.2%), and psoriasis vulgaris (n = 1,197, 1.1%) were identified. The prevalence of CHD in patients with hypertension, dyslipidemia, diabetes, and psoriasis vulgaris were 21.3%, 22.2%, 21.1%, and 9.0%, respectively. In 1,197 psoriasis patients, those with CHD were older, more likely to be male, and had more number of the diseases surveyed by ICD-10 codes. Multivariate analysis showed that psoriasis vulgaris was an independent associated factor for CHD (adjusted odds ratio [OR]: 1.27; 95% confidence interval [CI]: 1.01-1.58; p = 0.0404) along with hypertension (adjusted OR: 7.78; 95% CI: 7.25-8.36; p < 0.0001), dyslipidemia (adjusted OR: 2.35; 95% CI: 2.19-2.52; p < 0.0001), and diabetes (adjusted OR: 2.86; 95% CI: 2.67-3.06; p < 0.0001).
CONCLUSION
Psoriasis vulgaris was independently associated with CHD in a hospital-based population in Japan.
背景
寻常型银屑病是一种具有免疫遗传背景的慢性炎症性皮肤病。在美国和欧洲，它已被报道为冠心病（CHD）的独立危险因素。本研究的目的是调查日本一家医院人群中银屑病与冠心病之间的关联。
方法
对于2011年1月1日至2013年1月1日期间在我们机构住院和门诊的113,065名患者，使用医疗计费系统和电子病历提取冠心病、高血压、血脂异常、糖尿病和寻常型银屑病的诊断国际疾病分类（ICD）-10编码，并进行分析。
结果
确定了冠心病（n = 5,167，4.5%）、高血压（n = 16,476，14.5%）、血脂异常（n = 9,236，8.1%）、糖尿病（n = 11,555，10.2%）和寻常型银屑病（n = 1,197，1.1%）的患病率。高血压、血脂异常、糖尿病和寻常型银屑病患者中冠心病的患病率分别为21.3%、22.2%、21.1%和9.0%。在1,197例银屑病患者中，患有冠心病的患者年龄更大，更可能为男性，并且根据ICD-10编码调查的疾病数量更多。多变量分析显示，寻常型银屑病与冠心病是独立相关因素（调整后的优势比[OR]：1.27；95%置信区间[CI]：1.01-1.58；p = 0.0404），同时还有高血压（调整后的OR：7.78；95%CI：7.25-8.36；p < 0.0001）、血脂异常（调整后的OR：2.35；95%CI：2.19-2.52；p < 0.0001）和糖尿病（调整后的OR：2.86；95%CI：2.67-3.06；p < 0.0001）。
结论
在日本一家医院人群中，寻常型银屑病与冠心病独立相关。
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