Dart A M, Riemersma R A, Oliver M F
Department of Medicine, University of Edinburgh, U.K.
Atherosclerosis. 1989 Dec;80(2):119-24. doi: 10.1016/0021-9150(89)90019-1.
The effect of dietary supplementation with 20 capsules/day Maxepa or olive oil on serum lipids has been studied in 21 hypercholesterolaemic patients using a double-blind crossover design. Platelet membrane eicosapentaenoic acid percentage rose by more than 10-fold after 2 months dietary supplementation with Maxepa. Total serum cholesterol was unchanged and there was a rise in LDL-cholesterol and HDL-cholesterol concentration in men, but no change in LDL-cholesterol, and a fall in HDL-cholesterol in women. In men and women there was a marked fall in total serum triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. Thus, Maxepa is not an effective treatment for isolated hypercholesterolaemia.
采用双盲交叉设计，对21名高胆固醇血症患者进行了研究，以探讨每日补充20粒Maxepa胶囊或橄榄油对血脂的影响。在补充Maxepa饮食2个月后，血小板膜二十碳五烯酸百分比上升了10倍以上。男性的总血清胆固醇没有变化，低密度脂蛋白胆固醇和高密度脂蛋白胆固醇浓度有所上升，但女性的低密度脂蛋白胆固醇没有变化，高密度脂蛋白胆固醇有所下降。男性和女性的总血清甘油三酯、极低密度脂蛋白甘油三酯和极低密度脂蛋白胆固醇水平均显著下降。因此，Maxepa不是治疗单纯高胆固醇血症的有效方法。
