DiBartolomeo Mara E, Claud Erika C
The University of Chicago, Chicago, Illinois.
The University of Chicago, Chicago, Illinois.
Clin Ther. 2016 Apr;38(4):733-9. doi: 10.1016/j.clinthera.2016.02.003. Epub 2016 Mar 2.
To determine the importance of the neonatal microbiome in intestinal and overall health.
A review of existing literature.
The microbiome is increasingly understood to have a significant role in health and disease. However, the microbiome of the preterm infant is unique, with simple microbial communities exposed to a consistent diet in a regulated environment, and development from naive to stable under the influence of the neonatal intensive care unit. This early microbiome encounters a still developing host and thus has the potential to program fundamental pathways with implications for neonatal and later outcomes.
确定新生儿微生物群在肠道健康和整体健康中的重要性。
对现有文献进行综述。
人们越来越认识到微生物群在健康和疾病中发挥着重要作用。然而，早产儿的微生物群是独特的，其简单的微生物群落处于受调控环境中，饮食一致，并在新生儿重症监护病房的影响下从幼稚状态发展为稳定状态。这种早期的微生物群遇到的是仍在发育的宿主，因此有可能对基本通路进行编程，从而影响新生儿期及之后的结局。
