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使用语义网技术生成特定领域模板以支持临床研究元数据标准。

Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards.

作者信息

Jiang Guoqian, Evans Julie, Endle Cory M, Solbrig Harold R, Chute Christopher G

机构信息

Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905 USA.

Clinical Data Interchange Standards Consortium (CDISC), Austin, TX USA.

出版信息

J Biomed Semantics. 2016 Mar 3;7:10. doi: 10.1186/s13326-016-0053-5. eCollection 2016.

DOI:10.1186/s13326-016-0053-5
PMID:26949508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4778326/
Abstract

BACKGROUND

The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development.

METHODS

We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates.

RESULTS

A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6).

CONCLUSIONS

Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.

摘要

背景

生物医学研究集成领域组（BRIDG）模型是一种用于协议驱动的生物医学研究的正式领域分析模型，为标准制定组织（SDO）中的应用程序和消息开发提供语义基础。BRIDG模型日益复杂，需要新的方法来管理和利用基础语义，以协调特定领域的标准。本研究的目的是开发和评估一种基于语义网的方法，该方法将BRIDG模型与ISO 21090数据类型集成，以生成特定领域的模板，支持临床研究元数据标准的制定。

方法

我们基于开源资源描述框架（RDF）存储后端、基于SmartGWT的Web用户界面以及用于可视化生成的特定领域模板的基于“思维导图”的工具，开发了一个模板生成和可视化系统。我们还根据临床信息建模倡议（CIMI）参考模型开发了一个RESTful Web服务，以访问生成的特定领域模板。

结果

进行了一项初步可用性研究，所有评审人员（n = 3）对评估问题在可用性和满足系统要求的能力方面都给予了非常积极的回应（平均得分4.6）。

结论

语义网技术提供了一个可扩展的基础设施，在实现医疗保健和临床研究交叉领域模型的可计算语义互操作性方面具有巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/eb621efa91c4/13326_2016_53_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/669c9e63efca/13326_2016_53_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/d7b3e6a17fc7/13326_2016_53_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/2b0c576e4ba8/13326_2016_53_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/6d74f9796fb6/13326_2016_53_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/7888baf09751/13326_2016_53_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/eb621efa91c4/13326_2016_53_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/669c9e63efca/13326_2016_53_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/d7b3e6a17fc7/13326_2016_53_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/2b0c576e4ba8/13326_2016_53_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/6d74f9796fb6/13326_2016_53_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/7888baf09751/13326_2016_53_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7445/4778326/eb621efa91c4/13326_2016_53_Fig6_HTML.jpg

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