Irino Tomoyuki, Tsai Jon A, Ericson Jessica, Nilsson Magnus, Lundell Lars, Rouvelas Ioannis
Center for Digestive Diseases, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
Division of Surgery, CLINTEC, Karolinska Institute, Huddinge, 141 86, Stockholm, Sweden.
Langenbecks Arch Surg. 2016 May;401(3):315-22. doi: 10.1007/s00423-016-1396-1. Epub 2016 Mar 9.
Minimally invasive esophagectomy (MIE) has been met with increased interest for the surgical treatment of esophageal cancer. One critical obstacle for the implementation of MIE has been the intrathoracic anastomosis. In this study, we describe a technique of thoracoscopic intrathoracic anastomosis using a linear stapler in prone position and present the short-term outcomes of this procedure.
This prospective pilot study included 46 consecutive patients with a cancer either of the gastroesophageal junction (GEJ) or the distal esophagus who underwent either total MIE or thoracoscopic-assisted esophagectomy followed by intrathoracic stapled side-to-side anastomosis. The short-term outcomes including postoperative complications were recorded and analyzed.
This pilot study included 41 males (89 %) and 5 females (11 %) with a mean age of 65.7 years. The majority had adenocarcinoma (93 %). Before surgery, 4 patients (8.7 %) had an incomplete endoscopic submucosal resection, 5 patients (11 %) received chemotherapy alone, and 33 patients (71 %) had chemoradiotherapy. Mean operation time was 408 minutes. Postoperative complications classified as Clavien-Dindo Grade IIIa or more severe occurred in 7 patients (15 %), of whom 4 patients (8.7 %) developed anastomotic leakages without any need for intensive care. Another 2 patients (4.3 %) required intensive care due to aspiration pneumonia and acute renal failure. No in-hospital mortality was registered. Only one patient (2.2 %) with anastomotic leakage developed postoperative anastomotic stenosis requiring balloon dilatation.
The intrathoracic stapled side-to-side anastomosis technique seems to be feasible, safe, and easy to perform, associated with a limited postsurgical complication rate and a good functional outcome.
微创食管切除术(MIE)在食管癌手术治疗中越来越受到关注。实施MIE的一个关键障碍是胸内吻合术。在本研究中,我们描述了一种在俯卧位使用线性吻合器进行胸腔镜胸内吻合术的技术,并展示了该手术的短期结果。
这项前瞻性试点研究纳入了46例连续的胃食管交界(GEJ)或食管远端癌患者,他们接受了全MIE或胸腔镜辅助食管切除术,随后进行胸内吻合器侧侧吻合术。记录并分析包括术后并发症在内的短期结果。
该试点研究包括41名男性(89%)和5名女性(11%),平均年龄为65.7岁。大多数为腺癌(93%)。术前,4例患者(8.7%)内镜下黏膜下切除不完全,5例患者(11%)仅接受化疗,33例患者(71%)接受了放化疗。平均手术时间为408分钟。7例患者(15%)发生了Clavien-Dindo IIIa级或更严重的术后并发症,其中4例患者(8.7%)发生吻合口漏,无需重症监护。另外2例患者(4.3%)因吸入性肺炎和急性肾衰竭需要重症监护。无院内死亡记录。仅1例吻合口漏患者(2.2%)术后发生吻合口狭窄,需要球囊扩张。
胸内吻合器侧侧吻合术似乎可行、安全且易于实施,术后并发症发生率有限,功能结果良好。