Grobbel Julia, Dietzsch Janko, Johnson Chris A, Vonthein Reinhard, Stingl Katarina, Weleber Richard G, Schiefer Ulrich
Centre for Ophthalmology/Institute for Ophthalmic Research, University of Tübingen, Germany.
Department of Ophthalmology and Visual Sciences and Wynn Institute for Vision Research, University of Iowa, Iowa City, IA, USA.
Transl Vis Sci Technol. 2016 Mar 4;5(2):5. doi: 10.1167/tvst.5.2.5. eCollection 2016 Mar.
To determine normal values of the visual field (VF), corrected for age and reaction time (RT) for semiautomated kinetic perimetry (SKP) on the Octopus 900 perimeter, create a model describing the age-dependency of these values, and assess test-retest reliability for each isopter.
Eighty-six eyes of 86 ophthalmologically healthy subjects (age 11-79 years, 34 males, 52 females) underwent full-field kinetic perimetry with the Octopus 900 instrument. Stimulus size, luminance, velocity, meridional angle, subject age, and their interactions, were used to create a smooth multiple regression mathematical model (V/4e, III/4e, I/4e, I/3e, I/2e, I/1e, and I/1a isopters). Fourteen subjects (2 from each of 7 age groups) were evaluated on three separate sessions to assess test-retest reliability of the isopters. Reaction time (RT) was tested by presenting 12 designated RT-vectors between 10° and 20° within the seeing areas for the III/4e isopter (stimulus velocity, 3°/second). Four RT- vectors were presented at the nasal (0° or 180°), superotemporal (45°), and inferior (270°) meridians.
The model fit was excellent ( = 0.94). The test-retest variability was less than 5°, and the median decrease in this deviation attributed to aging, per decade, for all age groups and for all stimulus sizes was 0.8°. No significant learning effect was observed for any age group or isopter.
Age-corrected and RT-corrected normative threshold values for full-field kinetic perimetry can be adequately described by a smooth multiple linear regression mathematical model.
A description of the entire kinetic VF is useful for assessing a full characterization of VF sensitivity, determining function losses associated with ocular and neurologic diseases, and for providing a more comprehensive analysis of structure-function relationships.
确定在Octopus 900视野计上进行半自动动态视野检查（SKP）时，经年龄和反应时间（RT）校正后的视野（VF）正常值，创建一个描述这些值的年龄依赖性的模型，并评估每个等视线的重测可靠性。
86名眼科健康受试者（年龄11 - 79岁，男性34名，女性52名）的86只眼睛使用Octopus 900仪器进行了全视野动态视野检查。刺激大小、亮度、速度、子午线角度、受试者年龄及其相互作用，被用于创建一个平滑多元回归数学模型（V/4e、III/4e、I/4e、I/3e、I/2e、I/1e和I/1a等视线）。14名受试者（7个年龄组每组2名）在三个不同时间段接受评估，以评估等视线的重测可靠性。通过在III/4e等视线的可见区域内10°至20°之间呈现12个指定的RT向量来测试反应时间（RT）（刺激速度为3°/秒）。在鼻侧（0°或180°）、颞上（45°）和下方（270°）子午线处呈现4个RT向量。
模型拟合良好（ = 0.94）。重测变异性小于5°，所有年龄组和所有刺激大小每十年因衰老导致的该偏差中位数下降为0.8°。未观察到任何年龄组或等视线有显著的学习效应。
全视野动态视野检查的年龄校正和RT校正的正常阈值可以通过平滑多元线性回归数学模型充分描述。
整个动态视野的描述对于评估视野敏感性的全面特征、确定与眼部和神经系统疾病相关的功能损失以及提供结构 - 功能关系的更全面分析是有用的。
