Study course Ophthalmic Optics/Optometry, Aalen University of Applied Sciences, Aalen, Germany.
Competence Center Vision Research / Study course Ophthalmic Optics/Optometry, Aalen University of Applied Sciences, Aalen, Germany.
PLoS One. 2021 Dec 20;16(12):e0260362. doi: 10.1371/journal.pone.0260362. eCollection 2021.
Horizontal visual field extension was assessed for red and white stimuli in subjects with protanopia using semi-automated kinetic perimetry. In contrast to a conventional anomaloscope, the "red/white dissociation ratio" (RWR) allows to describe protanopia numerically. For the majority of subjects with protanopia a restriction for faint red stimuli was found.
Comparing the horizontal visual field extensions for red and white stimuli in subjects with protanopia and those with normal trichromacy and assessing the related intra-subject intra-session repeatability.
The subjects were divided into groups with protanopia and with normal trichromacy, based on color vision testing (HMC anomaloscope, Oculus, Wetzlar/FRG). Two stimulus characteristics, III4e and III1e, according to the Goldmann-classification, were presented with semi-automated kinetic perimetry (Octopus 900 perimeter, Haag-Streit, Köniz/CH). They moved along the horizontal meridian, with an angular velocity of 3°/s towards the visual field center, starting from either the temporal or nasal periphery. If necessary, a 20° nasal fixation point offset was chosen to capture the temporal periphery of the visual field. For each condition the red/white dissociation ratio (RWR); Pat Appl. DPMA DRN 43200082D) between the extent of the isopter for red (RG610, Schott, Mainz/ FRG) and white stimuli along the horizontal meridian was determined.
All data are listed as median/interquartile range: Five males with protanopia (age 22.1/4.5 years) and six males with normal trichromacy (control group, age 30.5/15.2 years) were enrolled. The RWR is listed for the right eye, as no clinically relevant difference between right and left eye occurred. Protanopes' RWR for mark III4e (in brackets: control group) was 0.941/0.013 (0.977/0.019) and for mark III1e 0.496/0.062 (0.805/0.051), respectively.
In this exploratory "proof-of-concept study" red/white dissociation ratio perimetry is introduced as a novel technique aiming at assessing and quantifying the severity of protanopia. Further effort is needed to understand the magnitude of the observed red-/white dissociation and to extend this methodology to a wider age range of the sample and to anomalous trichromacies (protanomalia) with varying magnitude.
使用半自动动态视野计评估红绿色觉异常者的红色和白色刺激的水平视野扩展。与传统的异常比色计相比，“红/白分离比”（RWR）允许对红绿色觉异常者进行数值描述。对于大多数红绿色觉异常者，发现对微弱的红色刺激有一定限制。
比较红绿色觉异常者和正常三色觉者的红色和白色刺激的水平视野扩展，并评估相关的受试者内和会话内可重复性。
根据颜色视觉测试（HMC 异常比色计，Oculus，Wetzlar/FRG），将受试者分为红绿色觉异常组和正常三色觉组。根据 Goldmann 分类，选择两个刺激特征 III4e 和 III1e，用半自动动态视野计（Haag-Streit，Köniz/CH 的 Octopus 900 周边仪）进行检测。刺激以 3°/s 的角速度向视野中心移动，起始于颞侧或鼻侧周边。如果需要，选择 20°鼻侧固定点偏移以捕获视野的颞侧周边。对于每种情况，均确定红色/白色分离比（RWR）；Pat Appl. DPMA DRN 43200082D）沿水平子午线的红色（RG610，Schott，美因茨/FRG）和白色刺激的同视曲线之间的比值。
所有数据均以中位数/四分位数范围列出：纳入 5 名男性红绿色觉异常者（年龄 22.1/4.5 岁）和 6 名男性正常三色觉者（对照组，年龄 30.5/15.2 岁）。右眼列出了 RWR，因为右眼和左眼之间没有临床相关差异。红绿色觉异常者的 III4e 标记的 RWR（括号内为对照组）为 0.941/0.013（0.977/0.019），III1e 标记的 RWR 为 0.496/0.062（0.805/0.051）。
在这项探索性的“概念验证研究”中，引入了红色/白色分离比视野测量法作为一种新的技术，旨在评估和量化红绿色觉异常的严重程度。需要进一步努力来理解观察到的红/白分离的程度，并将这种方法扩展到更广泛的样本年龄范围和不同程度的异常三色觉（红绿色觉异常）。
