Wickramasinghe S N, Marjot D H, Rosalki S B, Fink R S
Department of Haematology, St Mary's Hospital Medical School, London.
J Clin Pathol. 1989 Mar;42(3):295-9. doi: 10.1136/jcp.42.3.295.
A strong and highly significant correlation was observed between serum aspartate transaminase (AST) activity and an index of the cytotoxic activity associated with serum proteins modified by acetaldehyde in a group of 24 heavy drinkers. A weaker but significant correlation (R = 0.564, p = 0.008) was found between total serum creatine kinase activity and this index of serum cytotoxicity. As it is likely that the concentration of circulating modified protein was largely determined by the quantity of free acetaldehyde generated in the liver and that the AST activity was mainly derived from damaged hepatocytes, the data indicate a correlation between hepatic acetaldehyde generation and hepatocyte damage. This correlation may indicate either that increased quantities of acetaldehyde are released by damaged hepatocytes or that acetaldehyde is hepatotoxic in vivo. As only the creatine kinase isoenzyme present in skeletal muscle (CK-MM) was demonstrable in the serum in all but one of our patients, the data also suggest that circulating modified serum proteins may be toxic towards skeletal muscle cells.
在一组24名重度饮酒者中，观察到血清天冬氨酸转氨酶（AST）活性与乙醛修饰的血清蛋白相关的细胞毒性活性指标之间存在强烈且高度显著的相关性。总血清肌酸激酶活性与该血清细胞毒性指标之间存在较弱但显著的相关性（R = 0.564，p = 0.008）。由于循环中修饰蛋白的浓度很可能在很大程度上由肝脏中产生的游离乙醛量决定，且AST活性主要源自受损肝细胞，这些数据表明肝脏乙醛生成与肝细胞损伤之间存在相关性。这种相关性可能表明受损肝细胞释放出的乙醛量增加，或者乙醛在体内具有肝毒性。由于除一名患者外，我们所有患者的血清中仅能检测到骨骼肌中存在的肌酸激酶同工酶（CK-MM），这些数据还表明循环中的修饰血清蛋白可能对骨骼肌细胞有毒性。
