Qian Jingyi, Scheer Frank A J L
Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA.
Trends Endocrinol Metab. 2016 May;27(5):282-293. doi: 10.1016/j.tem.2016.03.005. Epub 2016 Apr 11.
The circadian system serves one of the most fundamental properties present in nearly all organisms: it generates 24-h rhythms in behavioral and physiological processes and enables anticipating and adapting to daily environmental changes. Recent studies indicate that the circadian system is important in regulating the daily rhythm in glucose metabolism. Disturbance of this circadian control or of its coordination relative to the environmental/behavioral cycle, such as in shift work, eating late, or due to genetic changes, results in disturbed glucose control and increased type 2 diabetes risk. Therefore, an in-depth understanding of the mechanisms underlying glucose regulation by the circadian system and its disturbance may help in the development of therapeutic interventions against the deleterious health consequences of circadian disruption.
它在行为和生理过程中产生24小时节律，并使生物体能够预测和适应日常环境变化。最近的研究表明，昼夜节律系统在调节葡萄糖代谢的日常节律方面很重要。这种昼夜节律控制或其与环境/行为周期的协调性受到干扰，如轮班工作、晚餐吃得晚或由于基因变化，会导致葡萄糖控制紊乱和2型糖尿病风险增加。因此，深入了解昼夜节律系统调节葡萄糖的机制及其紊乱情况，可能有助于开发针对昼夜节律紊乱有害健康后果的治疗干预措施。
