可控的水汽透过率通过促进伤口再上皮化和增强收缩来促进伤口愈合。
Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement.
作者信息
Xu Rui, Xia Hesheng, He Weifeng, Li Zhichao, Zhao Jian, Liu Bo, Wang Yuzhen, Lei Qiang, Kong Yi, Bai Yang, Yao Zhihui, Yan Rongshuai, Li Haisheng, Zhan Rixing, Yang Sisi, Luo Gaoxing, Wu Jun
机构信息
Institute of Burn Research, Southwest Hospital; State Key Lab of Trauma, Burn and Combined Injury; Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University, Chongqing 400038, China.
State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
出版信息
Sci Rep. 2016 Apr 18;6:24596. doi: 10.1038/srep24596.
A desirable microenvironment is essential for wound healing, in which an ideal moisture content is one of the most important factors. The fundamental function and requirement for wound dressings is to keep the wound at an optimal moisture. Here, we prepared serial polyurethane (PU) membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. It was found that the dressing with a WVTR of 2028.3 ± 237.8 g/m(2)·24 h was able to maintain an optimal moisture content for the proliferation and regular function of epidermal cells and fibroblasts in a three-dimensional culture model. Moreover, the dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. Our finds may be helpful in the design of wound dressing for wound regeneration in the future.
理想的微环境对于伤口愈合至关重要，其中理想的水分含量是最重要的因素之一。伤口敷料的基本功能和要求是使伤口保持在最佳湿度。在此，我们制备了具有分级水蒸气透过率（WVTRs）的系列聚氨酯（PU）膜敷料，并通过体外和体内研究确定了用于伤口愈合的敷料的最佳WVTR。结果发现，WVTR为2028.3±237.8 g/m²·24 h的敷料能够在三维培养模型中为表皮细胞和成纤维细胞的增殖及正常功能维持最佳水分含量。此外，发现具有这种最佳WVTR的敷料能够在小鼠皮肤伤口模型中促进伤口愈合。我们的发现可能有助于未来设计用于伤口再生的伤口敷料。
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