Garg Hina, Bush Steffani, Gappmaier Eduard
Department of Physical Therapy (HG, EG) and the Department of Exercise and Sport Science (SB), University of Utah, Salt Lake City, UT, USA.
Int J MS Care. 2016 Mar-Apr;18(2):71-7. doi: 10.7224/1537-2073.2015-013.
Fatigue is a common symptom in people with multiple sclerosis (MS), but its associations with disability, functional mobility, depression, and quality of life (QOL) remain unclear. We aimed to determine the associations between different levels of fatigue and disability, functional mobility, depression, and physical and mental QOL in people with MS.
Eighty-nine individuals with MS (mean [SD] disease duration = 13.6 [9.8] years, mean [SD] Expanded Disability Status Scale [EDSS] score = 5.3 [1.5]) and no concurrent relapses were retrospectively analyzed. Participants were divided into two groups based on five-item Modified Fatigue Impact Scale (MFIS-5) scores: group LF (n = 32, MFIS-5 score ≤10 [low levels of fatigue]) and group HF (n = 57, MFIS-5 score >10 [high levels of fatigue]).
Sixty-four percent of the sample reported high levels of fatigue. Compared with group LF, group HF demonstrated significantly (P < .05) greater impairments in the Timed Up and Go test, Activities-specific Balance Confidence scale, and 12-item Multiple Sclerosis Walking Scale scores; depression; and QOL but not in the EDSS scores, which were not significantly different between groups.
Fatigue was found to be a predominant symptom in the study participants. Individuals reporting higher levels of fatigue concomitantly exhibited greater impairments in functional mobility, depression, and physical and mental QOL. Disability was not found to be related to level of fatigue. These findings can be important for appropriate assessment and management of individuals with MS with fatigue.
疲劳是多发性硬化症（MS）患者的常见症状，但其与残疾、功能活动能力、抑郁和生活质量（QOL）之间的关联仍不明确。我们旨在确定MS患者不同程度的疲劳与残疾、功能活动能力、抑郁以及身心健康QOL之间的关联。
对89例无并发复发的MS患者（平均[标准差]病程 = 13.6 [9.8]年，平均[标准差]扩展残疾状态量表[EDSS]评分 = 5.3 [1.5]）进行回顾性分析。根据五项简化疲劳影响量表（MFIS-5）评分将参与者分为两组：LF组（n = 32，MFIS-5评分≤10 [低疲劳水平]）和HF组（n = 57，MFIS-5评分>10 [高疲劳水平]）。
64%的样本报告有高疲劳水平。与LF组相比，HF组在定时起立行走测试、特定活动平衡信心量表和12项多发性硬化症步行量表评分、抑郁及QOL方面的损害显著更大（P < .05）；但在EDSS评分方面两组无显著差异。
在研究参与者中，疲劳是主要症状。报告较高疲劳水平的个体在功能活动能力、抑郁以及身心健康QOL方面同时表现出更大的损害。未发现残疾与疲劳水平相关。这些发现对于对有疲劳的MS患者进行适当评估和管理可能具有重要意义。
