Enck P, Merlin V, Erckenbrecht J F, Wienbeck M
Department of Internal Medicine, University Hospitals, Dusseldorf, Fed. Rep. Germany.
Gut. 1989 Apr;30(4):455-9. doi: 10.1136/gut.30.4.455.
Previous investigations of stress effects on gastric emptying, orocaecal, and colonic transit in rats have produced conflicting results. Here one type of stressor, a 'passive avoidance' situation, was used to investigate its effects on gastric emptying, orocaecal and colonic transit. After the rats had been trained to eat a standard amount of semisolid food, gastric emptying was determined (n = 12) by the food remaining in the stomach after various periods of rest, or stress exposure. Orocaecal transit (n = 14) was determined by breath hydrogen measurements after the food had been labelled with 1 g lactose. Colonic transit (n = 18) was measured as the arrival time of coloured faeces after infusion of a carmine red solution into the caecum through a chronically implanted catheter. The stressor had differential effects on transit through the stomach, small bowel and colon: gastric emptying was delayed (p less than 0.05) after stress (t1/2 = 2.66 h after stress, 1.97 h at rest). Orocaecal transit was accelerated (p less than 0.05) after stress; transit time decreased from 124.3 min at rest to 86.2 min after stress. Colonic transit was accelerated (p less than 0.01) under stress, from 15.5 h to 1.29 h. It is concluded that gastrointestinal transit in different parts of the gastrointestinal tract is differently affected by central nervous stimuli.
先前关于应激对大鼠胃排空、口盲肠及结肠转运影响的研究结果相互矛盾。在此，采用一种应激源，即“被动回避”情境，来研究其对胃排空、口盲肠及结肠转运的影响。在训练大鼠进食标准量的半固体食物后，通过在不同休息或应激暴露时间段后胃内剩余食物量来测定胃排空（n = 12）。在用1 g乳糖标记食物后，通过呼气氢测量来测定口盲肠转运（n = 14）。通过经长期植入导管向盲肠注入胭脂红溶液后，测量有色粪便的到达时间来测定结肠转运（n = 18）。该应激源对胃、小肠和结肠的转运有不同影响：应激后胃排空延迟（p < 0.05）（应激后t1/2 = 2.66 h，休息时为1.97 h）。应激后口盲肠转运加速（p < 0.05）；转运时间从休息时的124.3分钟降至应激后的86.2分钟。应激状态下结肠转运加速（p < 0.01），从15.5小时降至1.29小时。结论是，胃肠道不同部位的胃肠转运受中枢神经刺激的影响不同。
