Dong Yujie, Zhou Ying, Chu Xixia, Chen Shiqing, Chen Lei, Yang Beimeng, Zhang Xu, Wang Lin, Wang Shuai, Lou Jingyu, Deng Qing, Wang Li, Cao Zheyi, Wang Jianan, Xie Jiaxin, Serdyuk Tatiana, Li Shengtian, He Lin, Chen Xiaoping, Li Weidong
Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Shanghai Elli Dental Clinic, No.26 South Yili Road, Shanghai, China.
Mol Brain. 2016 May 10;9(1):50. doi: 10.1186/s13041-016-0229-z.
Studies have indicated that depressive disorders are observed frequently in dentists. It's suggested that dentists encounter numerous sources of stress in their professional career. We noticed that the noises in dental environments are very unpleasant. The animal modeling studies suggested that stressful noise could produce depressive-like phenotypes in rodent animals. We hypothesize that the dental noise may be one of the primary stressors causing depressive disorders in dentists.
We treated C57BL/6 mice with programmatically played wide-spectrum dental noise for 8 h/day at 75 ± 10 dB SPL level for 30 days, and then tested the behaviors. After exposure to dental noise, animals displayed the depressive-like phenotypes, accompanied by inhibition of neurogenesis in hippocampus. These deficits were ameliorated by orally administered with antidepressant fluoxetine.
Our results suggested that dental noise could be one of the primary stressors for the pathogenesis of depressive disorders and the dental noise mouse model could be used in further depression studies.
研究表明，抑郁症在牙医中很常见。据推测，牙医在其职业生涯中会遇到众多压力源。我们注意到牙科环境中的噪音非常令人不快。动物模型研究表明，应激性噪音可在啮齿动物中产生类似抑郁的表型。我们假设牙科噪音可能是导致牙医患抑郁症的主要压力源之一。
我们以75±10 dB SPL的水平，每天8小时，对C57BL/6小鼠进行程序化播放的广谱牙科噪音处理，持续30天，然后测试其行为。暴露于牙科噪音后，动物表现出类似抑郁的表型，同时海马体中的神经发生受到抑制。口服抗抑郁药氟西汀可改善这些缺陷。
我们的结果表明，牙科噪音可能是抑郁症发病机制的主要压力源之一，牙科噪音小鼠模型可用于进一步的抑郁症研究。
