Pappas A C, Tsiplakou E, Tsitsigiannis D I, Georgiadou M, Iliadi M K, Sotirakoglou K, Zervas G
a Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture , Agricultural University of Athens , Athens , Greece.
b Department of Plant Pathology, Faculty of Crop Science , Agricultural University of Athens , Athens , Greece.
Br Poult Sci. 2016 Aug;57(4):551-8. doi: 10.1080/00071668.2016.1187712. Epub 2016 Aug 2.
Concomitant presence of mycotoxins is more likely to appear than a single mycotoxicosis since many mycotoxigenic fungi grow and produce their toxic metabolites under similar conditions. The present study was designed to evaluate the efficacy of 4 mycotoxin binders to protect meat-type chickens against single and concomitant administration in the feed of two mycotoxins, namely aflatoxin B1 (AFB1) and ochratoxin A (OTA) both at concentration of 0.1 mg/kg. A total of 440 as hatched, d-old, Ross 308 broilers were reared for 42 d. There were 11 dietary treatments. Chickens were fed on either an uncontaminated basal diet, basal diet and AFB1, basal with concomitant presence of AFB1 and OTA, basal diet and three binders A, B and C (1%) with or without AFB1 or basal diet and binder D (0.5%) with or without concomitant presence of AFB1 and OTA. Performance, carcass yield and several biochemical parameters were examined. Mycotoxin concentration in liver and breast muscle samples was determined. Broiler performance under concomitant mycotoxin contamination was poorer than that under single mycotoxicosis. Mycotoxin presence increased relative heart weight compared to that of broilers fed on uncontaminated diets. Only OTA and not AFB1 was detected and only in the liver. OTA concentration was four-fold lower in broilers fed on a diet with binder compared to those fed on contaminated diets without binder. In conclusion, the study revealed that binder composition and presence or not of multiple toxins may be important factors for optimum broiler performance under mycotoxicosis.
由于许多产毒真菌在相似条件下生长并产生其有毒代谢产物，因此霉菌毒素同时存在的情况比单一霉菌毒素中毒更有可能出现。本研究旨在评估4种霉菌毒素吸附剂对肉仔鸡的保护效果，这些肉仔鸡在饲料中分别单独或同时摄入两种霉菌毒素，即浓度均为0.1毫克/千克的黄曲霉毒素B1（AFB1）和赭曲霉毒素A（OTA）。总共440只刚出壳的1日龄罗斯308肉鸡饲养42天。共有11种日粮处理。给鸡饲喂未受污染的基础日粮、基础日粮加AFB1、基础日粮加AFB1和OTA同时存在、基础日粮加三种吸附剂A、B和C（1%）（有无AFB1）或基础日粮加吸附剂D（0.5%）（有无AFB1和OTA同时存在）。检测了生产性能、胴体产量和几个生化参数。测定了肝脏和胸肌样本中的霉菌毒素浓度。同时受到霉菌毒素污染的肉鸡生产性能比单一霉菌毒素中毒时更差。与饲喂未受污染日粮的肉鸡相比，霉菌毒素的存在增加了相对心脏重量。仅在肝脏中检测到OTA而未检测到AFB1。与饲喂未添加吸附剂的污染日粮的肉鸡相比，饲喂添加吸附剂日粮的肉鸡体内OTA浓度低四倍。总之，该研究表明，吸附剂组成以及多种毒素的存在与否可能是霉菌毒素中毒情况下肉仔鸡最佳生产性能的重要因素。
