Alqhtani Abdulmohsen H, Al Sulaiman Ali R, Abudabos Ala E
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, 11451, Riyadh, Saudi Arabia.
Environmental Protection Technologies Institute, Sustainability and Environment Sector, King Abdulaziz City for Science and Technology, P.O. Box 6086, 11442, Riyadh, Saudi Arabia.
Mycotoxin Res. 2025 Feb;41(1):25-35. doi: 10.1007/s12550-024-00567-w. Epub 2024 Oct 5.
To assess the efficacy of Toxfin and Novasil as aflatoxin-binding agents in broilers exposed to aflatoxin B (AFB) from 11 to 30 days, 288 mixed-sex Ross 308 broiler chickens were randomly allocated to four dietary groups: control feed, control feed + 0.25 mg/kg AFB, AFB feed + 0.3% Toxfin, and AFB feed + 0.3% Novasil. The evaluation encompassed growth performance for the grower (11-20 days), finisher (21-30 days), and overall (11-30 days) phases, carcass characteristics, serum biochemical components, liver function enzymes, hepatic antioxidant capacity, AFB residue in the liver and kidney, and ileal morphology at 30 days, and apparent nutrient digestibility during 29-30 days. Exposure to AFB significantly resulted in reduced growth efficiency, lowered carcass yields, liver hypertrophy, impaired metabolic and hepatic functions, liver oxidative stress, disrupted ileum architecture, diminished nutrient digestibility, and accumulated AFB in the liver and kidney. Conversely, supplementation of Toxfin or Novasil significantly augmented body weight gain (BWG) and reduced feed conversion ratio (FCR) during the finisher and overall phases, elevated BWG in the grower phase, heightened levels of glucose, hepatic protein, and glutathione peroxidase, declined malondialdehyde content, improved apparent metabolizable energy, and lowered AFB residues in the liver and kidney. Furthermore, Toxfin inclusion significantly reduced FCR during the grower phase, enhanced European production efficiency factor during the grower and overall phases, augmented dressing percentage, declined proportional liver weight, elevated concentrations of total protein, albumin, and total antioxidant capacity, heightened villus surface area, and boosted crude protein digestibility. To conclude, incorporating 0.3% Toxfin into broilers' feeds confers a more effectual safeguard than Novasil against the deleterious consequences of AFB exposure.
为评估脱毒菌素和诺维素作为黄曲霉毒素结合剂对11至30日龄暴露于黄曲霉毒素B（AFB）的肉鸡的功效，将288只混合性别的罗斯308肉鸡随机分为四个日粮组：对照饲料组、对照饲料+0.25mg/kg AFB组、AFB饲料+0.3%脱毒菌素组和AFB饲料+0.3%诺维素组。评估内容包括生长育肥期（11至20日龄）、育成期（21至30日龄）和整个阶段（11至30日龄）的生长性能、胴体特性、血清生化成分、肝功能酶、肝脏抗氧化能力、肝脏和肾脏中的AFB残留、30日龄时的回肠形态以及29至30日龄期间的表观养分消化率。暴露于AFB显著导致生长效率降低、胴体产量下降、肝脏肥大、代谢和肝功能受损、肝脏氧化应激、回肠结构破坏、养分消化率降低以及AFB在肝脏和肾脏中蓄积。相反，添加脱毒菌素或诺维素在育成期和整个阶段显著提高了体重增加（BWG）并降低了饲料转化率（FCR），在生长育肥期提高了BWG，提高了葡萄糖、肝脏蛋白质和谷胱甘肽过氧化物酶水平，降低了丙二醛含量，提高了表观代谢能，并降低了肝脏和肾脏中的AFB残留。此外，添加脱毒菌素在生长育肥期显著降低了FCR，在生长育肥期和整个阶段提高了欧洲生产效率因子，提高了屠宰率，降低了肝脏比例重量，提高了总蛋白、白蛋白浓度和总抗氧化能力，增加了绒毛表面积，并提高了粗蛋白消化率。总之，在肉鸡饲料中添加0.3%脱毒菌素比诺维素能更有效地保护肉鸡免受AFB暴露的有害影响。
