Alghadir Ahmad H, Gabr Sami A, Al-Eisa Einas S
Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia; Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Oxid Med Cell Longev. 2016;2016:2545168. doi: 10.1155/2016/2545168. Epub 2016 Apr 18.
We used a moderate aerobic exercise program for 24 weeks to measure the positive impact of physical activity on oxidative stress and inflammatory markers and its association with cognitive performance in healthy older adults. A total of 100 healthy subjects (65-95 Yrs) were randomly classified into two groups: control group (n = 50) and exercise group (n = 50). Cognitive functioning, physical activity score, MDA, 8-OHdG, TAC, and hs-CRP were assessed using LOTCA battery, prevalidated PA questionnaire, and immunoassay techniques. LOTCA 7-set scores of cognitive performance showed a significant correlation with physical activity status and the regulation of both oxidative stress free radicals and inflammatory markers in all older subjects following 24 weeks of moderate exercise. Physically active persons showed a higher cognitive performance along with reduction in the levels of MDA, 8-OHdG, and hs-CRP and increase in TAC activity compared with sedentary participants. Cognitive performance correlated positively with the increase in TAC activity and physical fitness scores and negatively with MDA, 8-OHdG, and hs-CRP, respectively. There was a significant improvement in motor praxis, vasomotor organization, thinking operations, and attention and concentration among older adults. In conclusion, moderate aerobic training for 24 weeks has a positive significant effect in improving cognitive functions via modulating redox and inflammatory status of older adults.
我们采用了一项为期24周的适度有氧运动计划，以测量体育活动对健康老年人氧化应激和炎症标志物的积极影响及其与认知表现的关联。共有100名健康受试者（65 - 95岁）被随机分为两组：对照组（n = 50）和运动组（n = 50）。使用洛文斯顿作业疗法认知评定成套测验（LOTCA）、预先验证的身体活动问卷和免疫测定技术评估认知功能、身体活动得分、丙二醛（MDA）、8 - 羟基脱氧鸟苷（8 - OHdG）、总抗氧化能力（TAC）和高敏C反应蛋白（hs - CRP）。在进行24周的适度运动后，所有老年受试者的LOTCA 7项认知表现得分与身体活动状态以及氧化应激自由基和炎症标志物的调节均显示出显著相关性。与久坐不动的参与者相比，身体活跃的人表现出更高的认知表现，同时MDA、8 - OHdG和hs - CRP水平降低，TAC活性增加。认知表现分别与TAC活性增加和身体素质得分呈正相关，与MDA、8 - OHdG和hs - CRP呈负相关。老年人的运动实践、血管运动组织、思维操作以及注意力和专注力有显著改善。总之，为期24周的适度有氧训练通过调节老年人的氧化还原和炎症状态，对改善认知功能具有积极显著的效果。
