Faculty of Dentistry, McGill University, 3640, Strathcona Anatomyand Dentistry Building, Rue University, Montreal, Quebec, H3A 0C7, Canada.
Division of Orthopaedics, Department of Surgery, Faculty of Medicine, McGill University, 1650 Cedar Ave, Montreal General Hospital, Montreal, Quebec, H3G 1A4, Canada.
Adv Healthc Mater. 2016 Jul;5(13):1646-55. doi: 10.1002/adhm.201600052. Epub 2016 May 23.
Vertical bone augmentation procedures are frequently carried out to allow successful placement of dental implants in otherwise atrophic ridges and represent one of the most common bone grafting procedures currently performed. Onlay autografting is one of the most prevalent and predictable techniques to achieve this; however, there are several well documented complications and drawbacks associated with it and synthetic alternatives are being sought. Monetite is a bioresorbable dicalcium phosphate with osteoconductive and osteoinductive potential that has been previously investigated for onlay bone grafting and it is routinely made by autoclaving brushite to simultaneously sterilize and phase convert. In this study, monetite disc-shaped grafts are produced by both wet and dry heating methods which alter their physical properties such as porosity, surface area, and mechanical strength. Histological observations after 12 weeks of onlay grafting on rabbit calvaria reveal higher bone volume (38%) in autoclaved monetite grafts in comparison with the dry heated monetite grafts (26%). The vertical bone height gained is similar for both the types of monetite grafts (up to 3.2 mm). However, it is observed that the augmented bone height is greater in the lateral than the medial areas of both types of monetite grafts. It is also noted that the higher porosity of autoclaved monetite grafts increases the bioresorbability, whereas the dry heated monetite grafts having lower porosity but higher surface area resorb to a significantly lesser extent. This study provides information regarding two types of monetite onlay grafts prepared with different physical properties that can be further investigated for clinical vertical bone augmentation applications.
垂直骨增量程序常用于在其他萎缩的牙槽嵴中成功植入牙种植体，是目前最常见的骨移植程序之一。骨块移植是实现这一目标的最常见和最可预测的技术之一；然而，它也有几个有据可查的并发症和缺点，因此正在寻找合成替代品。磷灰石是一种具有生物可吸收性的二钙磷酸盐，具有骨传导性和骨诱导性，以前曾被用于骨块移植研究，它通常通过高压灭菌来同时进行消毒和相转变。在这项研究中，通过湿加热和干加热两种方法生产磷灰石盘状移植物，这两种方法改变了它们的物理性质，如孔隙率、表面积和机械强度。在兔颅骨上进行 12 周的骨块移植后进行组织学观察，结果显示，与干热磷灰石移植物（26%）相比，高压灭菌磷灰石移植物中的骨体积（38%）更高。两种类型的磷灰石移植物获得的垂直骨高度相似（高达 3.2 毫米）。然而，观察到在两种类型的磷灰石移植物的外侧区域增加的骨高度大于内侧区域。还注意到，高压灭菌磷灰石移植物的高孔隙率增加了生物可吸收性，而具有较低孔隙率但较高表面积的干热磷灰石移植物的吸收程度要小得多。这项研究提供了关于两种具有不同物理性质的磷灰石骨块移植的信息，可进一步研究其用于临床垂直骨增量的应用。
