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金黄节菱孢霉菌合成银纳米颗粒及其对念珠菌属、曲霉属和镰刀菌属的抗真菌活性。

Biosynthesis of silver nanoparticles by the fungus Arthroderma fulvum and its antifungal activity against genera of Candida, Aspergillus and Fusarium.

作者信息

Xue Baiji, He Dan, Gao Song, Wang Dongyang, Yokoyama Koji, Wang Li

机构信息

Department of Pathogenobiology, Jilin University Mycology Research Center, Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

出版信息

Int J Nanomedicine. 2016 May 4;11:1899-906. doi: 10.2147/IJN.S98339. eCollection 2016.

DOI:10.2147/IJN.S98339
PMID:27217752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4862354/
Abstract

The objective of this study was to find one or more fungal strains that could be utilized to biosynthesize antifungal silver nanoparticles (AgNPs). Using morphological and molecular methods, Arthroderma fulvum was identified as the most effective fungal strain for synthesizing AgNPs. The UV-visible range showed a single peak at 420 nm, which corresponded to the surface plasmon absorbance of AgNPs. X-ray diffraction and transmission electron microscopy demonstrated that the biosynthesized AgNPs were crystalline in nature with an average diameter of 15.5±2.5 nm. Numerous factors could potentially affect the process of biosynthesis, and the main factors are discussed here. Optimization results showed that substrate concentration of 1.5 mM, alkaline pH, reaction temperature of 55°C, and reaction time of 10 hours were the optimum conditions for AgNP biosynthesis. Biosynthesized AgNPs showed considerable activity against the tested fungal strains, including Candida spp., Aspergillus spp., and Fusarium spp., especially Candida spp.

摘要

本研究的目的是找到一种或多种可用于生物合成抗真菌银纳米颗粒（AgNP）的真菌菌株。通过形态学和分子方法，鉴定出黄节皮菌是合成AgNP最有效的真菌菌株。紫外可见光谱在420nm处显示出一个单峰，这对应于AgNP的表面等离子体吸收。X射线衍射和透射电子显微镜表明，生物合成的AgNP本质上是晶体，平均直径为15.5±2.5nm。许多因素可能会影响生物合成过程，本文讨论了主要因素。优化结果表明，1.5mM的底物浓度、碱性pH、55°C的反应温度和10小时的反应时间是AgNP生物合成的最佳条件。生物合成的AgNP对测试的真菌菌株，包括念珠菌属、曲霉属和镰刀菌属，尤其是念珠菌属，表现出相当大的活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/274c5be8e730/ijn-11-1899Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/4e1b0181e21e/ijn-11-1899Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/5eeb7d0c0f2c/ijn-11-1899Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/e098357360ea/ijn-11-1899Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/580c1ab764e6/ijn-11-1899Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/274c5be8e730/ijn-11-1899Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/4e1b0181e21e/ijn-11-1899Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/39fd9943a85c/ijn-11-1899Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/ae16508ad309/ijn-11-1899Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/5eeb7d0c0f2c/ijn-11-1899Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/e098357360ea/ijn-11-1899Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/580c1ab764e6/ijn-11-1899Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d401/4862354/274c5be8e730/ijn-11-1899Fig7.jpg

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