在人类中检测到的首例G24P[14]轮状病毒株的分子特征分析。
Molecular characterization of the first G24P[14] rotavirus strain detected in humans.
作者信息
Ward M Leanne, Mijatovic-Rustempasic Slavica, Roy Sunando, Rungsrisuriyachai Kunchala, Boom Julie A, Sahni Leila C, Baker Carol J, Rench Marcia A, Wikswo Mary E, Payne Daniel C, Parashar Umesh D, Bowen Michael D
机构信息
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Texas Children's Hospital, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA.
出版信息
Infect Genet Evol. 2016 Sep;43:338-42. doi: 10.1016/j.meegid.2016.05.033. Epub 2016 May 26.
Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans.
在此，我们报告了一种新型轮状病毒A（RVA）毒株的基因组，该毒株是在美国疾病控制与预防中心新疫苗监测网络的常规监测期间，从一份粪便样本中检测到的。该毒株，RVA/人类-wt/美国/2012741499/2012/G24P[14]，其基因组组成为G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3。VP2、VP3、VP7和NSP3基因在系统发育上与牛毒株聚类。其他基因占据包含动物和人类毒株的混合进化枝。毒株RVA/人类-wt/美国/2012741499/2012/G24P[14]很可能是种间传播和重配事件的产物。这是G24基因型的第二篇报道，也是人类中G24P[14]基因型组合的首次报道。
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