Tam Ka Ian, Roy Sunando, Esona Mathew D, Jones Starlene, Sobers Stephanie, Morris-Glasgow Victoria, Rey-Benito Gloria, Gentsch Jon R, Bowen Michael D
Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Public Health Laboratory, Ministry of Health, Barbados.
Infect Genet Evol. 2014 Dec;28:524-9. doi: 10.1016/j.meegid.2014.09.020. Epub 2014 Sep 22.
Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel G-P combination of G4P[14], detected through PAHO surveillance in Barbados. Full genome sequencing of strain RVA/Human-wt/BRB/CDC1133/2012/G4P[14] revealed that its genotype is G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The possession of a Genogroup 1 (Wa-like) backbone distinguishes this strain from other P[14] rotavirus strains. Phylogenetic analyses suggested that this strain was likely generated by genetic reassortment between human, porcine and possibly other animal rotavirus strains and identified 7 lineages within the P[14] genotype. The results of this study reinforce the potential role of interspecies transmission in generating human rotavirus diversity through reassortment. Continued surveillance is important to determine if rotavirus vaccines will protect against strains that express the P[14] rotavirus genotype.
自2004年以来，泛美卫生组织（PAHO）一直在拉丁美洲和加勒比地区开展轮状病毒监测工作。在此，我们报告通过PAHO在巴巴多斯进行的监测所检测到的具有新型G-P组合G4P[14]的人轮状病毒的特征。毒株RVA/Human-wt/BRB/CDC1133/2012/G4P[14]的全基因组测序显示，其基因型为G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1。拥有基因组1型（Wa样）主干将该毒株与其他P[14]轮状病毒毒株区分开来。系统发育分析表明，该毒株可能是由人、猪以及可能的其他动物轮状病毒毒株之间的基因重配产生的，并在P[14]基因型内鉴定出7个谱系。本研究结果强化了种间传播在通过重配产生人轮状病毒多样性方面的潜在作用。持续监测对于确定轮状病毒疫苗是否能预防表达P[14]轮状病毒基因型的毒株很重要。
