Friedman Joseph H, Beck James C, Chou Kelvin L, Clark Gracia, Fagundes Christopher P, Goetz Christopher G, Herlofson Karen, Kluger Benzi, Krupp Lauren B, Lang Anthony E, Lou Jao-Shin, Marsh Laura, Newbould Anne, Weintraub Daniel
Movement Disorders Program, Butler Hospital, Province, RI, USA; Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.
Parkinson's Disease Foundation, New York, NY, USA.
NPJ Parkinsons Dis. 2016;2:15025-. doi: 10.1038/npjparkd.2015.25. Epub 2016 Jan 14.
Fatigue is a severe problem for many people living with Parkinson's disease (PD). Best estimates suggest that more than 50% of patients experience this debilitating symptom. Little is known about its etiology or treatment, making the understanding of fatigue a true unmet need. As part of the Parkinson's Disease Foundation Community Choice Research Program, patients, caregivers, and scientists attended a symposium on fatigue on 16 and 17 October 2014. We present a summary of that meeting, reviewing what is known about the diagnosis and treatment of fatigue, its physiology, and what we might learn from multiple sclerosis (MS), depression, and cancer-disorders in which fatigue figures prominently too. We conclude with focused recommendations to enhance our understanding and treatment of this prominent problem in PD.
疲劳是许多帕金森病（PD）患者面临的严重问题。据最佳估计，超过50%的患者会出现这种使人衰弱的症状。人们对其病因或治疗方法知之甚少，这使得对疲劳的了解成为一个真正未得到满足的需求。作为帕金森病基金会社区选择研究项目的一部分，患者、护理人员和科学家于2014年10月16日和17日参加了一次关于疲劳的研讨会。我们在此呈现该会议的总结，回顾关于疲劳的诊断和治疗、其生理学的已知情况，以及我们可能从多发性硬化症（MS）、抑郁症和癌症等疾病中学到的东西——在这些疾病中疲劳也很突出。我们最后提出重点建议，以加强我们对帕金森病中这一突出问题的理解和治疗。
