Usman Afia, Ahmad Masood
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.
Chemosphere. 2016 Sep;158:131-42. doi: 10.1016/j.chemosphere.2016.05.070. Epub 2016 Jun 1.
Bisphenol-A (BPA) is one of the most abundant synthetic chemicals in the world due to its uses in plastics. Its widespread exposure vis-a-vis low dose effects led to a reduction in its safety dose and imposition of ban on its use in infant feeding bottles. This restriction paved the way for the gradual market entry of its analogues. However, their structural similarity to BPA has put them under surveillance for endocrine disrupting potential. The application of these analogues is increasing and so are the studies reporting their toxicity. This review highlights the reasons which led to the ban of BPA and also reports the exposure and toxicological data available on its analogues. Hence, this compilation is expected to answer in a better way whether the replacement of BPA by these analogues is safer or more harmful?
双酚A（BPA）因其在塑料中的应用而成为世界上最常见的合成化学品之一。由于其广泛暴露及其低剂量效应，导致其安全剂量降低，并禁止在婴儿奶瓶中使用。这一限制为其类似物逐步进入市场铺平了道路。然而，它们与双酚A的结构相似性使其因具有内分泌干扰潜力而受到监测。这些类似物的应用正在增加，报告其毒性的研究也在增加。本综述强调了导致双酚A被禁止的原因，并报告了其类似物的暴露和毒理学数据。因此，预计这一汇编将更好地回答用这些类似物替代双酚A是更安全还是更有害的问题？
