School of Molecular Sciences and The Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8860-3. doi: 10.1002/anie.201601944. Epub 2016 Jun 8.
Modular DNA tile-based self-assembly is a versatile way to engineer basic tessellation patterns on the nanometer scale, but it remains challenging to achieve high levels of structural complexity. We introduce a set of general design principles to create intricate DNA tessellations by employing multi-arm DNA motifs with low symmetry. We achieved two novel Archimedean tiling patterns, (4.8.8) and (3.6.3.6), and one pattern with higher-order structures beyond the complexity observed in Archimedean tiling. Our success in assembling complicated DNA tessellations demonstrates the broad design space of DNA structural motifs, enriching the toolbox of DNA tile-based self-assembly and expanding the complexity boundaries of DNA tile-based tessellation.
基于模块化 DNA 瓦片的自组装是在纳米尺度上构建基本镶嵌图案的一种通用方法，但要实现高水平的结构复杂性仍然具有挑战性。我们引入了一组通用设计原则，通过使用低对称的多臂 DNA 基元来创建复杂的 DNA 镶嵌图案。我们实现了两种新的阿基米德平铺模式，（4.8.8）和（3.6.3.6），以及一种具有高于阿基米德平铺复杂度的高阶结构的图案。我们成功组装了复杂的 DNA 镶嵌图案，展示了 DNA 结构基元的广阔设计空间，丰富了 DNA 瓦片自组装的工具包，并扩展了 DNA 瓦片镶嵌的复杂性边界。
