基于双交叉瓦片的完全可寻址DNA纳米结构的自组装。
Self-assembly of fully addressable DNA nanostructures from double crossover tiles.
作者信息
Wang Wen, Lin Tong, Zhang Suoyu, Bai Tanxi, Mi Yongli, Wei Bryan
机构信息
School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China Bioengineering Graduate Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Depatment of Chemistry, Tongji University, Shanghai 200092, China.
School of Life Sciences, Tsinghua University-Peking University Center for Life Sciences, Center for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China.
出版信息
Nucleic Acids Res. 2016 Sep 19;44(16):7989-96. doi: 10.1093/nar/gkw670. Epub 2016 Aug 2.
DNA origami and single-stranded tile (SST) are two proven approaches to self-assemble finite-size complex DNA nanostructures. The construction elements appeared in structures from these two methods can also be found in multi-stranded DNA tiles such as double crossover tiles. Here we report the design and observation of four types of finite-size lattices with four different double crossover tiles, respectively, which, we believe, in terms of both complexity and robustness, will be rival to DNA origami and SST structures.
DNA折纸术和单链瓦片（SST）是两种经证实的用于自组装有限尺寸复杂DNA纳米结构的方法。这两种方法所构建的结构中出现的构建元件，在诸如双交叉瓦片等多链DNA瓦片中也能找到。在此，我们分别报告了四种由四种不同双交叉瓦片构成的有限尺寸晶格的设计与观察结果，我们认为，就复杂性和稳健性而言，这些晶格将可与DNA折纸术和SST结构相媲美。
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