Conibear Anne C, Farbiarz Karine, Mayer Rupert L, Matveenko Maria, Kählig Hanspeter, Becker Christian F W
University of Vienna, Faculty of Chemistry, Institute of Biological Chemistry, Währinger Straße 38, 1090 Vienna, Austria.
Org Biomol Chem. 2016 Jul 14;14(26):6205-11. doi: 10.1039/c6ob00932h. Epub 2016 Jun 10.
Dehydroascorbate is a by-product of copper-catalysed azide-alkyne click (CuAAC) reactions and also forms advanced glycation end products (AGEs) in tissues undergoing oxidative stress. Here we isolate and characterize an arginine-dehydroascorbate adduct formed during CuAAC reactions, investigate strategies for preventing its formation, and propose its biological relevance as an AGE.
脱氢抗坏血酸是铜催化的叠氮化物-炔烃环加成反应（CuAAC）的副产物，并且在经历氧化应激的组织中也会形成晚期糖基化终产物（AGEs）。在此，我们分离并表征了在CuAAC反应过程中形成的精氨酸-脱氢抗坏血酸加合物，研究了防止其形成的策略，并提出了其作为一种AGE的生物学意义。
