Department of Regenerative Medicine, Houston Methodist Research Institute , Houston, TX , USA.
Department of Regenerative Medicine, Houston Methodist Research Institute, Houston, TX, USA; College of Materials Science and Engineering, University of Chinese Academy of Science, Beijing, China.
Front Bioeng Biotechnol. 2016 Jun 2;4:45. doi: 10.3389/fbioe.2016.00045. eCollection 2016.
The aim of tissue engineering is to promote the repair of functional tissues. For decades, the combined use of biomaterials, growth factors (GFs), and stem cells has been the base of several regeneration strategies. Among these, biomimicry emerged as a robust strategy to efficiently address this clinical challenge. Biomimetic materials, able to recapitulate the composition and architecture of the extracellular matrix, are the materials of choice, for their biocompatibility and higher rate of efficacy. In addition, it has become increasingly clear that restoring the complex biochemical environment of the target tissue is crucial for its regeneration. Toward this aim, the combination of scaffolds and GFs is required. The advent of nanotechnology significantly impacted the field of tissue engineering by providing new ways to reproduce the complex spatial and temporal biochemical patterns of tissues. This review will present the most recent approaches to finely control the spatiotemporal release of bioactive molecules for various tissue engineering applications.
组织工程的目的是促进功能性组织的修复。几十年来，生物材料、生长因子（GFs）和干细胞的联合使用一直是几种再生策略的基础。其中，仿生学已成为有效应对这一临床挑战的有力策略。能够模拟细胞外基质的组成和结构的仿生材料是首选材料，因为它们具有生物相容性和更高的疗效。此外，越来越明显的是，恢复靶组织的复杂生化环境对于其再生至关重要。为此，需要支架和 GFs 的组合。纳米技术的出现通过提供复制组织复杂时空生化模式的新方法，极大地推动了组织工程领域的发展。本文综述了最新的方法来精细控制生物活性分子的时空释放，以用于各种组织工程应用。
