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高山黄芩和高茎黄芩提取物及多酚对晚期糖基化终产物形成的抑制作用和抗氧化活性

Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.

作者信息

Grzegorczyk-Karolak Izabela, Gołąb Krzysztof, Gburek Jakub, Wysokińska Halina, Matkowski Adam

机构信息

Department of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90-151, Poland.

Department of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, Poland.

出版信息

Molecules. 2016 Jun 14;21(6):739. doi: 10.3390/molecules21060739.

Abstract

Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders.

摘要

两种黄芩属植物高山黄芩(Scutellaria alpina)和高茎黄芩(Scutellaria altissima)地上部分及根部的甲醇提取物,以及这些植物中的五种多酚类物质,在体外均表现出显著抑制晚期糖基化终产物(AGE)形成的能力。富含多酚类化合物的高山黄芩具有较强的抗糖基化特性。这些提取物在FRAP(铁还原抗氧化能力)、抗自由基(DPPH)和脂质过氧化抑制试验中也表现出高活性。在纯化合物中,黄芩苷是最强的糖基化抑制剂(100μg/mL时抑制率为90.4%),其次是木犀草素(85.4%)。另外两种黄酮苷的活性约为上述两者的一半。毛蕊花糖苷与参比药物氨基胍的活性相似(分别为71.2%和75.9%)。AGE抑制与总黄酮含量之间的强相关性表明,黄酮类化合物对抗糖基化特性有显著贡献。抗糖基化活性与抗氧化活性之间也存在正相关。所研究的黄芩属植物可被视为高血糖相关疾病治疗药物的潜在来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a6a/6273165/665a9aae8d21/molecules-21-00739-g001.jpg

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