Dezsényi Balázs, Strausz Tamás, Makrai Zita, Csomor Judit, Danka József, Kern Peter, Rezza Giovanni, Barth Thomas F E, Casulli Adriano
Joint Hospital of St. Stephen and St. Ladislau, Budapest, Hungary.
National Institute of Oncology, Budapest, Hungary.
Infection. 2017 Feb;45(1):107-110. doi: 10.1007/s15010-016-0918-7. Epub 2016 Jun 28.
Alveolar echinococcosis is a zoonotic parasitic disease causing a severe clinical condition and is known as the most deadly of all helminth infections. Moreover, this disease is also an increasing concern in Northern and Eastern Europe due to its spread in the wildlife animal host.
An asymptomatic 70-year-old woman from south-western Hungary was diagnosed with multiple liver lesions. Imaging techniques (ultrasound, computed tomography and magnetic resonance imaging), serology (ELISA, indirect hemagglutination and Western blot), and conventional staining methods (hematoxylin-eosin and periodic acid-Schiff) were used for the detection of the disease. A histopathological re-evaluation of formalin-fixed paraffin block by immunohistochemical staining with the monoclonal antibody Em2G11 definitively confirmed the diagnosis of alveolar echinococcosis.
To our knowledge, this is the first confirmed autochthonous case of human alveolar echinococcosis in Hungary. To what extent diagnostic difficulties may contribute to underestimate this zoonosis in Eastern Europe is unknown. Differential diagnosis with alveolar echinococcosis should be considered for patients with multiple, tumor-like cystic lesions of the liver, in countries where this parasite is emerging.
肺泡型棘球蚴病是一种人畜共患的寄生虫病，可导致严重的临床症状，被认为是所有蠕虫感染中最致命的。此外，由于其在野生动物宿主中的传播，这种疾病在北欧和东欧也日益受到关注。
一名来自匈牙利西南部的70岁无症状女性被诊断出患有多发性肝脏病变。采用影像学技术（超声、计算机断层扫描和磁共振成像）、血清学（酶联免疫吸附测定、间接血凝试验和免疫印迹法）以及传统染色方法（苏木精-伊红染色和过碘酸-希夫染色）来检测该疾病。通过用单克隆抗体Em2G11进行免疫组织化学染色对福尔马林固定石蜡块进行组织病理学重新评估，最终确诊为肺泡型棘球蚴病。
据我们所知，这是匈牙利首例确诊的人肺泡型棘球蚴病本土病例。在东欧，诊断困难在多大程度上可能导致对这种人畜共患病的低估尚不清楚。在这种寄生虫出现的国家，对于患有多发性、肿瘤样囊性肝脏病变的患者，应考虑与肺泡型棘球蚴病进行鉴别诊断。
