Janowsky J S, Shimamura A P, Kritchevsky M, Squire L R
Veterans Administration Medical Center, San Diego, California 92161.
Behav Neurosci. 1989 Jun;103(3):548-60. doi: 10.1037//0735-7044.103.3.548.
Whether frontal lobe pathology can account for some of the cognitive impairment observed in amnesic patients with Korsakoff's syndrome was investigated. Various cognitive and memory tests were given to patients with circumscribed frontal lobe lesions, patients with Korsakoff's syndrome, non-Korsakoff amnesic patients, and control Ss. Patients with frontal lobe lesions were not amnesic. Nevertheless they exhibited 2 deficits that were also exhibited by patients with Korsakoff's syndrome but not by other amnesic patients: (a) impairment on the Wisconsin Card Sorting Test and (b) impairment on the Initiation and Preservation subscale of the Dementia Rating Scale. Thus, frontal lobe pathology can explain some of the cognitive deficits observed in patients with Korsakoff's syndrome.
研究了额叶病变是否能解释在患有科尔萨科夫综合征的失忆症患者中观察到的一些认知障碍。对患有局限性额叶病变的患者、患有科尔萨科夫综合征的患者、非科尔萨科夫失忆症患者和对照组进行了各种认知和记忆测试。患有额叶病变的患者没有失忆。然而，他们表现出了两种缺陷，患有科尔萨科夫综合征的患者也有这些缺陷，但其他失忆症患者没有：（a）威斯康星卡片分类测试中的损伤，以及（b）痴呆评定量表的启动和保持分量表中的损伤。因此，额叶病变可以解释在患有科尔萨科夫综合征的患者中观察到的一些认知缺陷。
