微小RNA在呼吸道病毒感染中的作用：朋友还是敌人？
The role of microRNAs in respiratory viral infection: friend or foe?
作者信息
Tahamtan Alireza, Inchley Christopher S, Marzban Mona, Tavakoli-Yaraki Masoumeh, Teymoori-Rad Majid, Nakstad Britt, Salimi Vahid
机构信息
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway.
出版信息
Rev Med Virol. 2016 Nov;26(6):389-407. doi: 10.1002/rmv.1894. Epub 2016 Jul 4.
MicroRNAs (miRNAs) have emerged as a class of regulatory RNAs in host-pathogen interactions. Aberrant miRNA expression seems to play a central role in the pathology of several respiratory viruses, promoting development and progression of infection. miRNAs may thus serve as therapeutic and prognostic factors for respiratory viral infectious disease caused by a variety of agents. We present a comprehensive review of recent findings related to the role of miRNAs in different respiratory viral infections and discuss possible therapeutic opportunities aiming to attenuate the burden of viral infections. Our review supports the emerging concept that cellular and viral-encoded miRNAs might be broadly implicated in human respiratory viral infections, with either positive or negative effects on virus life cycle. Copyright © 2016 John Wiley & Sons, Ltd.
微小RNA（miRNA）已成为宿主-病原体相互作用中的一类调节性RNA。异常的miRNA表达似乎在几种呼吸道病毒的病理学中起着核心作用，促进感染的发展和进展。因此，miRNA可能作为由多种病原体引起的呼吸道病毒感染性疾病的治疗和预后因素。我们全面综述了与miRNA在不同呼吸道病毒感染中的作用相关的最新研究结果，并讨论了旨在减轻病毒感染负担的可能治疗机会。我们的综述支持了一个新出现的概念，即细胞和病毒编码的miRNA可能广泛参与人类呼吸道病毒感染，对病毒生命周期产生正面或负面影响。版权所有© 2016约翰威立父子有限公司。
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