干扰素处理后AKR小鼠细胞膜的物理、形态和生化改变。

Chang E H, Jay F T, Friedman R M

Proc Natl Acad Sci U S A. 1978 Apr;75(4):1859-63. doi: 10.1073/pnas.75.4.1859.

Interferon treatment of AKR,C- cells was followed by the establishment of an antiviral state and apparently concomitant morphological, physical, and biochemical alterations of the cell plasma membrane. The density of the plasma membrane was significant altered, and the concentration of some plasma membrane glycoproteins and the number of intramembranous particles observed in freeze-fracture electron micrographs were increased. A parallel increase in the concentration of intramembranous particles and the resistance to viral infection during interferon treatment as well as their parallel decrease upon removal of interferon suggests a relationship between the particle density and the establishment of the antiviral state.

用干扰素处理AKR、C细胞后，建立了抗病毒状态，同时细胞浆膜在形态、物理和生化方面也明显发生了改变。浆膜密度发生了显著变化，在冷冻断裂电子显微镜照片中观察到的一些浆膜糖蛋白的浓度和膜内颗粒的数量增加了。在干扰素处理期间，膜内颗粒浓度和抗病毒感染能力同时增加，而去除干扰素后它们又同时下降，这表明颗粒密度与抗病毒状态的建立之间存在关联。