脑-肠-微生物群轴：它在自闭症谱系障碍中起什么作用？
The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?
作者信息
Luna Ruth Ann, Savidge Tor C, Williams Kent C
机构信息
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, Texas, USA.
Department of Pediatric Gastroenterology, Nationwide Children's Hospital, Columbus, Ohio, USA.
出版信息
Curr Dev Disord Rep. 2016 Mar;3(1):75-81. doi: 10.1007/s40474-016-0077-7. Epub 2016 Feb 26.
Abstract
The brain-gut-microbiome axis refers to the interactions between the central nervous system, gastrointestinal system, and microorganisms that live in the gastrointestinal tract. Exploring these interactions provides a rationale for why gastrointestinal disorders commonly occur in children with Autism Spectrum Disorders (ASD). Signs of altered brain-gut interactions that are closely associated with functional GI disorders (FGIDs) commonly occur in children with ASD. Studies of microbiome in ASD suggest that changes in the gut microbiome may be associated with ASD and with GI disorders in children with ASD. Further studies into the brain-gut-microbiome axis could lead to new techniques for identifying GI disorders in children with ASD and novel therapies for treating ASD behaviors.
摘要
脑-肠-微生物群轴是指中枢神经系统、胃肠道系统以及生活在胃肠道中的微生物之间的相互作用。探索这些相互作用为自闭症谱系障碍（ASD）儿童中常见胃肠道疾病的原因提供了理论依据。与功能性胃肠疾病（FGIDs）密切相关的脑-肠相互作用改变的迹象在ASD儿童中很常见。对ASD中微生物群的研究表明，肠道微生物群的变化可能与ASD以及ASD儿童的胃肠道疾病有关。对脑-肠-微生物群轴的进一步研究可能会带来识别ASD儿童胃肠道疾病的新技术以及治疗ASD行为的新疗法。
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本文引用的文献
1
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PLoS One. 2015 Oct 1;10(10):e0137725. doi: 10.1371/journal.pone.0137725. eCollection 2015.
2
Microbes & neurodevelopment--Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala.微生物群与神经发育--生命早期缺乏微生物群会增加杏仁核中与活动相关的转录途径的活性。
Brain Behav Immun. 2015 Nov;50:209-220. doi: 10.1016/j.bbi.2015.07.009. Epub 2015 Jul 14.
3
Chelation for autism spectrum disorder (ASD).用于自闭症谱系障碍（ASD）的螯合疗法。
Cochrane Database Syst Rev. 2015 May 11;5(5):CD010766. doi: 10.1002/14651858.CD010766.pub2.
4
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms.研究和操控肠道微生物群以改善自闭症症状的方法。
Microb Ecol Health Dis. 2015 May 7;26:26878. doi: 10.3402/mehd.v26.26878. eCollection 2015.
5
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Intern Med. 2015;54(3):243-9. doi: 10.2169/internalmedicine.54.2710.
6
Measles outbreak in Greater Manchester, England, October 2012 to September 2013: epidemiology and control.2012 年 10 月至 2013 年 9 月英格兰大曼彻斯特麻疹疫情：流行病学和控制。
Euro Surveill. 2014 Dec 11;19(49):20982. doi: 10.2807/1560-7917.es2014.19.49.20982.
7
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Anal Bioanal Chem. 2014 Jul;406(19):4649-62. doi: 10.1007/s00216-014-7855-z. Epub 2014 May 15.
8
Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis.自闭症谱系障碍中的胃肠道症状：一项荟萃分析。
Pediatrics. 2014 May;133(5):872-83. doi: 10.1542/peds.2013-3995.
9
Altered gut microbiota and activity in a murine model of autism spectrum disorders.自闭症谱系障碍小鼠模型中的肠道微生物群改变和活性。
Brain Behav Immun. 2014 Mar;37:197-206. doi: 10.1016/j.bbi.2013.12.005. Epub 2013 Dec 11.
10
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.微生物组调节与神经发育障碍相关的行为和生理异常。
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