Scarano Antonio, Lorusso Felice, Ravera Lorenzo, Mortellaro Carmen, Piattelli Adriano
Department of Medical, Oral and Biotechnological Sciences and CeSI-MeT, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Biomed Res Int. 2016;2016:4086870. doi: 10.1155/2016/4086870. Epub 2016 May 30.
Background. Oral rehabilitation of partially fully edentulous patients with dental implants has become a routine procedure in clinical practice. In a site with a lack of bone GBR is a surgical procedure that provides an augmentation in terms of volume for the insertion of dental implants. Materials and Methods. In the iliac crest of six sheep 4 defects were created where an implant was inserted, three of them with different biomaterials and a control site. All animals were sacrificed after a 4-month healing period. All specimens were processed and analyzed with histomorphometry. Statistical evaluation was done to evaluate percentage of bone defect filled by new bone. Results. All experimental groups showed an increase of the new bone. Higher and highly statistically significant differences were found in the percentages of bone defect filled by new bone in group filled with corticocancellous 250-1000 microns particulate porcine bone mix. Conclusions. This study demonstrates that particulate porcine bone mix and porcine corticocancellous collagenate prehydrated bone mix when used as scaffold are able to induce bone regeneration. Moreover, these data suggest that these biomaterials have higher biocompatibility and are capable of inducing faster and greater bone formation.
背景。对于部分或完全无牙患者，采用牙种植体进行口腔修复已成为临床实践中的常规手术。在骨量不足的部位，引导骨再生术（GBR）是一种外科手术，可增加骨量以植入牙种植体。
材料与方法。在六只绵羊的髂嵴处制造了4个缺损，并在其中植入种植体，其中三个植入不同的生物材料，另设一个对照部位。在4个月的愈合期后，对所有动物实施安乐死。所有标本均经过处理并进行组织形态计量学分析。进行统计学评估以评价新骨填充骨缺损的百分比。
结果。所有实验组的新骨量均有所增加。在填充有250 - 1000微米颗粒状猪皮质骨松质混合骨的组中，新骨填充骨缺损的百分比存在更高且具有高度统计学意义的差异。
结论。本研究表明，颗粒状猪骨混合骨以及预水化的猪皮质骨松质胶原化混合骨用作支架时能够诱导骨再生。此外，这些数据表明这些生物材料具有更高的生物相容性，并且能够诱导更快、更多的骨形成。
