Mirsaeidi Mehdi, Omar Hesham R, Ebrahimi Golnaz, Campos Micheal
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.
Internal Medicine Department, Mercy Medical Center, Clinton, IA, USA.
Int J Hypertens. 2016;2016:2402515. doi: 10.1155/2016/2402515. Epub 2016 Jun 28.
Introduction. The association between the level of systemic inflammation and systemic hypertension (sHTN) among subjects with sarcoidosis has not been previously explored. Methods. A retrospective study was conducted to investigate the relation between the level of systemic inflammation in sarcoidosis, measured by various serum inflammatory markers, and sHTN. Results. Among a total of 108 cases with sarcoidosis (mean age: 53.4 years, 76.9% females), 55 (50.9%) had sHTN and 53 (49.1%) were normotensive. ESR was highly associated with sHTN. The patients with sHTN had higher mean ESR levels compared with normotensives (48.8 ± 35 versus 23.2 ± 27 mm/hr, resp.; P = 0.001). ROC curve analysis for ESR revealed an AUC value of 0.795 (95% CI: 0.692-0.897; P = 0.0001). With regard to CRP, there was a trend towards higher mean values in sHTN group (3.4 versus 1.7 mg/L; P = 0.067) and significantly higher prevalence of sHTN in the highest CRP quartile compared to the lowest one (69.6% versus 30%; OR 4.95; P = 0.017). ROC curve analysis for CRP revealed an AUC value of 0.644 (95% CI: 0.518-0.769; P = 0.03). On multivariate analysis, ESR and the CRP remained independent predictors for sHTN among subjects with sarcoidosis. Conclusion. Systemic inflammation is associated with the presence of sHTN in sarcoidosis.
引言。此前尚未探讨结节病患者全身炎症水平与系统性高血压（sHTN）之间的关联。方法。开展一项回顾性研究，以调查通过多种血清炎症标志物测量的结节病全身炎症水平与sHTN之间的关系。结果。在总共108例结节病患者中（平均年龄：53.4岁，76.9%为女性），55例（50.9%）患有sHTN，53例（49.1%）血压正常。红细胞沉降率（ESR）与sHTN高度相关。与血压正常者相比，sHTN患者的平均ESR水平更高（分别为48.8±35与23.2±27毫米/小时；P = 0.001）。ESR的ROC曲线分析显示曲线下面积（AUC）值为0.795（95%置信区间：0.692 - 0.897；P = 0.0001）。关于C反应蛋白（CRP），sHTN组的平均值有升高趋势（3.4与1.7毫克/升；P = 0.067），并且与最低四分位数相比，最高CRP四分位数中sHTN的患病率显著更高（69.6%对30%；比值比4.95；P = 0.017）。CRP的ROC曲线分析显示AUC值为0.644（95%置信区间：0.518 - 0.769；P = 0.03）。多变量分析显示，ESR和CRP仍然是结节病患者sHTN的独立预测因素。结论。全身炎症与结节病中sHTN的存在相关。
